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Science 6 April 2001:
Vol. 292. no. 5514, pp. 104 - 106
DOI: 10.1126/science.1057991
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Reports

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

David J. Clancy,1 David Gems,1* Lawrence G. Harshman,2 Sean Oldham,3 Hugo Stocker,3 Ernst Hafen,3 Sally J. Leevers,45 Linda Partridge1

The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

1 Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.
2 School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
3 Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
4 Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK.
5 Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
*   To whom correspondence should be addressed. E-mail: david.gems{at}ucl.ac.uk

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Sci. Aging Knowl. Environ. 2003, re2-2
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Genetic Loci Modulating Fitness and Life Span in Caenorhabditis elegans: Categorical Trait Interval Mapping in CL2a x Bergerac-BO Recombinant-Inbred Worms.
S. Ayyadevara, R. Ayyadevara, A. Vertino, A. Galecki, J. J. Thaden, and R. J. S. Reis (2003)
Genetics 163, 557-570
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Science. ISSN 0036-8075 (print), 1095-9203 (online)