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Science 16 March 2001: Vol. 291. no. 5511, pp. 2144 - 2147 DOI: 10.1126/science.1057586
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Reports
A Sperm Cytoskeletal Protein That Signals Oocyte Meiotic Maturation and Ovulation
Michael A. Miller,1
Viet Q. Nguyen,2
Min-Ho Lee,3
Mary Kosinski,1
Tim Schedl,3
Richard M. Caprioli,2
David Greenstein1*
Caenorhabditis elegans oocytes, like those of
most animals, arrest during meiotic prophase. Sperm promote the
resumption of meiosis (maturation) and contraction of smooth
muscle-like gonadal sheath cells, which are required for ovulation. We
show that the major sperm cytoskeletal protein (MSP) is a bipartite
signal for oocyte maturation and sheath contraction. MSP also functions
in sperm locomotion, playing a role analogous to actin. Thus, during evolution, MSP has acquired extracellular signaling and intracellular cytoskeletal functions for reproduction. Proteins with MSP-like domains
are found in plants, fungi, and other animals, suggesting that related
signaling functions may exist in other phyla.
1 Department of Cell Biology,
2 Mass Spectrometry Research Center, Vanderbilt
University School of Medicine, Nashville, TN 37232, USA.
3 Department of Genetics, Washington University
School of Medicine, St. Louis, MO 63110, USA.
*
To whom correspondence should be addressed. E-mail:
david.greenstein{at}mcmail.vanderbilt.edu
Read the Full Text
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