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Originally published in Science Express on 1 February 2001
Science 2 March 2001:
Vol. 291. no. 5509, pp. 1755 - 1759
DOI: 10.1126/science.1057206
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Research Articles

An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

Andrew T. McKie,1* Dalna Barrow,1 Gladys O. Latunde-Dada,1 Andreas Rolfs,6 Giamal Sager,2 Elida Mudaly,2 Melitta Mudaly,2 Christopher Richardson,5 David Barlow,5 Adrian Bomford,4 Timothy J. Peters,2 Kishor B. Raja,2 Sima Shirali,2 Matthias A. Hediger,6 Farzin Farzaneh,1 Robert J. Simpson23

The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase activity that displays adaptive responses to iron status. We have isolated a complementary DNA, Dcytb (for duodenal cytochrome b), which encoded a putative plasma membrane di-heme protein in mouse duodenal mucosa. Dcytb shared between 45 and 50% similarity to the cytochrome b561 family of plasma membrane reductases, was highly expressed in the brush-border membrane of duodenal enterocytes, and induced ferric reductase activity when expressed in Xenopus oocytes and cultured cells. Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway.

1 Department of Molecular Medicine, Guy's, King's and St. Thomas' School of Medicine, King's College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK.
2 Department of Clinical Biochemistry,
3 Department of Diabetes Endocrinology and Internal Medicine,
4 Institute of Liver Studies, Guy's, King's and St. Thomas' School of Medicine, King's College London, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK.
5 Department of Pharmacy, King's College London, Franklin-Wilkins Building, Waterloo Campus, 150 Stamford Street, London SE1 8WA, UK.
6 Membrane Biology Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
*   To whom correspondence should be addressed. E-mail: andrew.t.mckie{at}kcl.ac.uk

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