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Originally published in Science Express on 18 January 2001
Science 2 February 2001:
Vol. 291. no. 5505, pp. 872 - 875
DOI: 10.1126/science.1056782
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Reports

Lack of Replicative Senescence in Normal Rodent Glia

Nicole F. Mathon, Denise S. Malcolm, Marie C. Harrisingh, Lili Cheng, Alison C. Lloyd*

Replicative senescence is thought to be an intrinsic mechanism for limiting the proliferative life-span of normal somatic cells. We show here that rat Schwann cells can be expanded indefinitely in culture while maintaining checkpoints normally lost during the immortalization process. These findings demonstrate that senescence is not an inevitable consequence of extended proliferation in culture.

MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
*   To whom correspondence should be addressed. E-mail: alison.lloyd{at}ucl.ac.uk

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