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Science 12 January 2001:
Vol. 291. no. 5502, pp. 306 - 309
DOI: 10.1126/science.291.5502.306
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Reports

A Role for Flavin Monooxygenase-Like Enzymes in Auxin Biosynthesis

Yunde Zhao,12 Sioux K. Christensen,2* Christian Fankhauser,2dagger John R. Cashman,3 Jerry D. Cohen,4 Detlef Weigel,2 Joanne Chory12ddagger

Although auxin is known to regulate many processes in plant development and has been studied for over a century, the mechanisms whereby plants produce it have remained elusive. Here we report the characterization of a dominant Arabidopsis mutant, yucca, which contains elevated levels of free auxin. YUCCA encodes a flavin monooxygenase-like enzyme and belongs to a family that includes at least nine other homologous Arabidopsis genes, a subset of which appears to have redundant functions. Results from tryptophan analog feeding experiments and biochemical assays indicate that YUCCA catalyzes hydroxylation of the amino group of tryptamine, a rate-limiting step in tryptophan-dependent auxin biosynthesis.

1 Howard Hughes Medical Institute,
2 Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
3 The Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA.
4 Department of Horticultural Science, University of Minnesota, Saint Paul, MN 55108, USA.
*   Present address: Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 2124 Life Sciences Box 951606, Los Angeles, CA 90095-1606, USA.

dagger    Present address: Department of Molecular Biology, 30 quai Ernest Ansermet, 1211 Geneve 4, Switzerland.

ddagger    To whom correspondence should be addressed. E-mail: chory{at}salk.edu

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