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Science 5 January 2001:
Vol. 291. no. 5501, pp. 128 - 130
DOI: 10.1126/science.291.5501.128
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Reports

Chromosomal Effects of Rapid Gene Evolution in Drosophila melanogaster

Dmitry Nurminsky,1 Daniel De Aguiar,2 Carlos D. Bustamante,3 Daniel L. Hartl3*

Rapid adaptive fixation of a new favorable mutation is expected to affect neighboring genes along the chromosome. Evolutionary theory predicts that the chromosomal region would show a reduced level of genetic variation and an excess of rare alleles. We have confirmed these predictions in a region of the X chromosome of Drosophila melanogaster that contains a newly evolved gene for a component of the sperm axoneme. In D. simulans, where the novel gene does not exist, the pattern of genetic variation is consistent with selection against recurrent deleterious mutations. These findings imply that the pattern of genetic variation along a chromosome may be useful for inferring its evolutionary history and for revealing regions in which recent adaptive fixations have taken place.

1 Department of Anatomy and Cell Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
2 U.S. Department of Agriculture-Agriculture Research Service, Center for Medical, Agricultural and Veterinary Entomology, 1700 S.W. 23rd Drive, Gainesville, FL 32604, USA.
3 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02137, USA.
*   To whom correspondence should be addressed. E-mail: dhartl{at}oeb.harvard.edu

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