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Science 8 December 2000:
Vol. 290. no. 5498, pp. 1975 - 1978
DOI: 10.1126/science.290.5498.1975
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Reports
Multigenerational Cortical Inheritance of the Rax2 Protein in Orienting Polarity and Division in Yeast
Tracy Chen,1
Takatoshi Hiroko,2
Amitabha Chaudhuri,1
Fumika Inose,2
Matthew Lord,1
Shigeko Tanaka,2
John Chant,1*
Atsushi Fujita2*
Diploid yeast cells repeatedly polarize and bud from their poles,
probably because of highly stable marks of unknown composition. Here,
Rax2, a membrane protein, was shown to behave as such a mark. The Rax2
protein itself was inherited immutably at the cell cortex for multiple
generations, and Rax2 was shown to have a half-life exceeding several
generations. The persistent inheritance of cortical protein markers
would provide a means to couple a cell's history to the future
development of a precise morphogenetic form.
1 Department of Molecular and Cellular Biology,
Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
2 National Institute of Bioscience & Human
Technology, AIST 1-1 Higashi, Tsukuba 305-8566, Japan.
*
To whom correspondence should be addressed. E-mail:
chant{at}fas.harvard.edu (J.C.) and atsushi{at}nibh.go.jp
(A.F.).
Read the Full Text
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