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Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
Éva Mezey,1*Karen J. Chandross,2Gyöngyi Harta,1Richard A. Maki,34Scott R. McKercher3
Bone marrow stem cells give rise to a variety of hematopoietic
lineages and repopulate the blood throughout adult life. Weshow that,
in a strain of mice incapable of developing cells ofthe myeloid and
lymphoid lineages, transplanted adult bone marrowcells migrated into
the brain and differentiated into cells thatexpressed neuron-specific
antigens. These findings raise the possibilitythat bone
marrow-derived cells may provide an alternative sourceof neurons in
patients with neurodegenerative diseases or centralnervous system
injury.
1 Basic Neuroscience Program,
2 Laboratory of Developmental Neurogenetics,
National Institute of Neurological Disorders and Stroke, National
Institutes of Health, Bethesda, MD 20892, USA.
3 The
Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
4 Neurocrine Biosciences, 10555 Science Center
Drive, San Diego, CA 92121, USA.
*
To whom correspondence should be addressed. E-mail:
mezey{at}codon.nih.gov
The editors suggest the following Related Resources on Science sites:
In Science Magazine
NEWS FOCUS
Gretchen Vogel (1 December 2000) Science290 (5497), 1672.
[DOI: 10.1126/science.290.5497.1672] |Summary »|Full Text »
NEWS FOCUS
Gretchen Vogel (1 December 2000) Science290 (5497), 1673.
[DOI: 10.1126/science.290.5497.1673] |Summary »|Full Text »
REPORTS
Timothy R. Brazelton, Fabio M. V. Rossi, Gilmor I. Keshet, and Helen M. Blau (1 December 2000) Science290 (5497), 1775.
[DOI: 10.1126/science.290.5497.1775] |Abstract »|Full Text »|PDF »|Supplemental Data »
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Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye.
A. Kicic, W.-Y. Shen, A. S. Wilson, I. J. Constable, T. Robertson, and P. E. Rakoczy (2003)
J. Neurosci.
23, 7742-7749
|Abstract »|Full Text »|PDF »
Circulating Vascular Progenitor Cells Do Not Contribute to Compensatory Lung Growth.
R. Voswinckel, T. Ziegelhoeffer, M. Heil, S. Kostin, G. Breier, T. Mehling, R. Haberberger, M. Clauss, A. Gaumann, W. Schaper, et al. (2003)
Circ. Res.
93, 372-379
|Abstract »|Full Text »|PDF »
Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells.
S. Wislet-Gendebien, P. Leprince, G. Moonen, and B. Rogister (2003)
J. Cell Sci.
116, 3295-3302
|Abstract »|Full Text »|PDF »
Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis.
J. Imitola, E. Y. Snyder, and S. J. Khoury (2003)
Physiol Genomics
14, 171-197
|Abstract »|Full Text »|PDF »
Adult Stem Cells for Tissue Repair -- A New Therapeutic Concept?.
M. Korbling and Z. Estrov (2003)
N. Engl. J. Med.
349, 570-582
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Skeletal muscle engraftment potential of adult mouse skin side population cells.
F. Montanaro, K. Liadaki, J. Volinski, A. Flint, and L. M. Kunkel (2003)
PNAS
100, 9336-9341
|Abstract »|Full Text »|PDF »
J. C. Segovia, G. Guenechea, J. M. Gallego, J. M. Almendral, and J. A. Bueren (2003)
J. Virol.
77, 8495-8503
|Abstract »|Full Text »|PDF »
Human Pulmonary Chimerism after Hematopoietic Stem Cell Transplantation.
B. T. Suratt, C. D. Cool, A. E. Serls, L. Chen, M. Varella-Garcia, E. J. Shpall, K. K. Brown, and G. S. Worthen (2003)
Am. J. Respir. Crit. Care Med.
168, 318-322
|Abstract »|Full Text »|PDF »
Adult Cardiac Stem Cells--Where Do We Go from Here?.
J. M. Edelberg, M. Xaymardan, S. Rafii, and M. K. Hong (2003)
Sci. Aging Knowl. Environ.
2003, pe17-17
|Abstract »|Full Text »
Ewing Tumor Fusion Proteins Block the Differentiation of Pluripotent Marrow Stromal Cells.
E. C. Torchia, S. Jaishankar, and S. J. Baker (2003)
Cancer Res.
63, 3464-3468
|Abstract »|Full Text »|PDF »
