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Science 1 December 2000:
Vol. 290. no. 5497, pp. 1779 - 1782
DOI: 10.1126/science.290.5497.1779
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Reports

Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow

Éva Mezey,1* Karen J. Chandross,2 Gyöngyi Harta,1 Richard A. Maki,34 Scott R. McKercher3

Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.

1 Basic Neuroscience Program,
2 Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
3 The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
4 Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA.
*   To whom correspondence should be addressed. E-mail: mezey{at}codon.nih.gov

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