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Science 1 December 2000:
Vol. 290. no. 5497, pp. 1775 - 1779
DOI: 10.1126/science.290.5497.1775
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Reports

From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice

Timothy R. Brazelton, Fabio M. V. Rossi, Gilmor I. Keshet, Helen M. Blau*

After intravascular delivery of genetically marked adult mouse bone marrow into lethally irradiated normal adult hosts, donor-derived cells expressing neuronal proteins (neuronal phenotypes) developed in the central nervous system. Flow cytometry revealed a population of donor-derived cells in the brain with characteristics distinct from bone marrow. Confocal microscopy of individual cells showed that hundreds of marrow-derived cells in brain sections expressed gene products typical of neurons (NeuN, 200-kilodalton neurofilament, and class III beta -tubulin) and were able to activate the transcription factor cAMP response element-binding protein (CREB). The generation of neuronal phenotypes in the adult brain 1 to 6 months after an adult bone marrow transplant demonstrates a remarkable plasticity of adult tissues with potential clinical applications.

Department of Molecular Pharmacology, CCSR 4215, 269 Campus Drive, Stanford University, Stanford, CA 94305-5175, USA.
*   To whom correspondence should be addressed. E-mail: hblau{at}stanford.edu

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A. D. Ho and M. Punzel (2003)
J. Leukoc. Biol. 73, 547-555
   Abstract »    Full Text »    PDF »
Origin and use of embryonic and adult stem cells in differentiation and tissue repair.
R. Passier and C. Mummery (2003)
Cardiovasc Res 58, 324-335
   Abstract »    Full Text »    PDF »
Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.
M. Krampera, S. Glennie, J. Dyson, D. Scott, R. Laylor, E. Simpson, and F. Dazzi (2003)
Blood 101, 3722-3729
   Abstract »    Full Text »    PDF »
An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells.
T. Kai and A. Spradling (2003)
PNAS 100, 4633-4638
   Abstract »    Full Text »    PDF »
Primitive Cells and Tissue Regeneration.
P. Anversa, J. Kajstura, B. Nadal-Ginard, and A. Leri (2003)
Circ. Res. 92, 579-582
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Neural Stem Cells: An Overview.
R. Galli, A. Gritti, L. Bonfanti, and A. L. Vescovi (2003)
Circ. Res. 92, 598-608
   Abstract »    Full Text »    PDF »
Cellular origins of atherosclerosis: towards ontogenetic endgame?.
T. M. DOHERTY, P. K. SHAH, and T. B. RAJAVASHISTH (2003)
FASEB J 17, 592-597
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Human embryonic stem cells: research, ethics and policy.
G. d. Wert and C. Mummery (2003)
Hum. Reprod. 18, 672-682
   Abstract »    Full Text »    PDF »
Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains.
J. M. Weimann, C. A. Charlton, T. R. Brazelton, R. C. Hackman, and H. M. Blau (2003)
PNAS 100, 2088-2093
   Abstract »    Full Text »    PDF »


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