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Science 10 November 2000: Vol. 290. no. 5494, pp. 1151 - 1155 DOI: 10.1126/science.290.5494.1151
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Reports
The Evolutionary Fate and Consequences of Duplicate Genes
Michael Lynch,1*
and John S. Conery2
Gene duplication has generally been viewed as a necessary source of
material for the origin of evolutionary novelties, but it is unclear
how often gene duplicates arise and how frequently they evolve new
functions. Observations from the genomic databases for several
eukaryotic species suggest that duplicate genes arise at a very high
rate, on average 0.01 per gene per million years. Most duplicated genes
experience a brief period of relaxed selection early in their history,
with a moderate fraction of them evolving in an effectively neutral
manner during this period. However, the vast majority of gene
duplicates are silenced within a few million years, with the few
survivors subsequently experiencing strong purifying selection.
Although duplicate genes may only rarely evolve new functions, the
stochastic silencing of such genes may play a significant role in the
passive origin of new species.
1 Department of Biology, University of Oregon,
Eugene, OR 97403, USA.
2 Department of Computer and
Information Science, University of Oregon, Eugene, OR 97403, USA.
*
To whom correspondence should be addressed. E-mail:
mlynch{at}oregon.uoregon.edu
Read the Full Text
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| Full Text »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- J. C. Havird, M. M. Miyamoto, K. P. Choe, and D. H. Evans (2008)
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25, 2349-2359
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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148, 1721-1733
| Abstract »
| Full Text »
| PDF »
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PNAS
105, 16659-16664
| Abstract »
| Full Text »
| PDF »
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- S. Dorus, Z. N. Freeman, E. R. Parker, B. D. Heath, and T. L. Karr (2008)
Mol. Biol. Evol.
25, 2157-2166
| Abstract »
| Full Text »
| PDF »
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148, 993-1003
| Abstract »
| Full Text »
| PDF »
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- S. Vij, J. Giri, P. K. Dansana, S. Kapoor, and A. K. Tyagi (2008)
Mol Plant
1, 732-750
| Abstract »
| Full Text »
| PDF »
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- Q. Zhou, G. Zhang, Y. Zhang, S. Xu, R. Zhao, Z. Zhan, X. Li, Y. Ding, S. Yang, and W. Wang (2008)
Genome Res.
18, 1446-1455
| Abstract »
| Full Text »
| PDF »
- Preservation of a Pseudogene by Gene Conversion and Diversifying Selection.
- S. Takuno, T. Nishio, Y. Satta, and H. Innan (2008)
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180, 517-531
| Abstract »
| Full Text »
| PDF »
- Duplication of Teichoic Acid Biosynthetic Genes in Staphylococcus aureus Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases.
- M. P. Pereira, M. A. D'Elia, J. Troczynska, and E. D. Brown (2008)
J. Bacteriol.
190, 5642-5649
| Abstract »
| Full Text »
| PDF »
- Clinical, Agricultural, and Evolutionary Biology of Myostatin: A Comparative Review.
- B. D. Rodgers and D. K. Garikipati (2008)
Endocr. Rev.
29, 513-534
| Abstract »
| Full Text »
| PDF »
- A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR.
- M. Resch, H. Striegl, E. M. Henssler, M. Sevvana, C. Egerer-Sieber, E. Schiltz, W. Hillen, and Y. A. Muller (2008)
Nucleic Acids Res.
36, 4390-4401
| Abstract »
| Full Text »
| PDF »
- Gene Dosage and Gene Duplicability.
- W. Qian and J. Zhang (2008)
Genetics
179, 2319-2324
| Abstract »
| Full Text »
| PDF »
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- Z. Xie, X. Li, B. J. Glover, S. Bai, G.-Y. Rao, J. Luo, and J. Yang (2008)
Mol. Biol. Evol.
25, 1581-1592
| Abstract »
| Full Text »
| PDF »
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- G. C. Conant and K. H. Wolfe (2008)
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179, 1681-1692
| Abstract »
| Full Text »
| PDF »
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- R. Hovav, B. Chaudhary, J. A. Udall, L. Flagel, and J. F. Wendel (2008)
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179, 1725-1733
| Abstract »
| Full Text »
| PDF »
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- A. I. Taylor, H. J. Gould, B. J. Sutton, and R. A. Calvert (2008)
J. Biol. Chem.
283, 16384-16390
| Abstract »
| Full Text »
| PDF »
- Origin of INSL3-mediated testicular descent in therian mammals.
- J.-I. Park, J. Semyonov, C. L. Chang, W. Yi, W. Warren, and S. Y. T. Hsu (2008)
Genome Res.
18, 974-985
| Abstract »
| Full Text »
| PDF »
- Antagonistic Jacalin-Related Lectins Regulate the Size of ER Body-Type {beta}-Glucosidase Complexes in Arabidopsis thaliana.
- A. J. Nagano, Y. Fukao, M. Fujiwara, M. Nishimura, and I. Hara-Nishimura (2008)
Plant Cell Physiol.
49, 969-980
| Abstract »
| Full Text »
| PDF »
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- P. Grzmil, D. Boinska, K. C. Kleene, I. Adham, G. Schluter, M. Kamper, B. Buyandelger, A. Meinhardt, S. Wolf, and W. Engel (2008)
Biol Reprod
78, 958-967
| Abstract »
| Full Text »
| PDF »
- Evolutionary Origins of a Novel Host Plant Detoxification Gene in Butterflies.
- H. M. Fischer, C. W. Wheat, D. G. Heckel, and H. Vogel (2008)
Mol. Biol. Evol.
25, 809-820
| Abstract »
| Full Text »
| PDF »
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- R. Hovav, J. A. Udall, B. Chaudhary, R. Rapp, L. Flagel, and J. F. Wendel (2008)
PNAS
105, 6191-6195
| Abstract »
| Full Text »
| PDF »
- Sequence Level Analysis of Recently Duplicated Regions in Soybean [Glycine max (L.) Merr.] Genome.
- K. Van, D. H. Kim, C. M. Cai, M. Y. Kim, J. H. Shin, M. A. Graham, R. C. Shoemaker, B.-S. Choi, T.-J. Yang, and S.-H. Lee (2008)
DNA Res
15, 93-102
| Abstract »
| Full Text »
| PDF »
- Divergence Times in Caenorhabditis and Drosophila Inferred from Direct Estimates of the Neutral Mutation Rate.
- A. D. Cutter (2008)
Mol. Biol. Evol.
25, 778-786
| Abstract »
| Full Text »
| PDF »
- Adaptive Evolution of the Insulin Two-Gene System in Mouse.
- M.-S. Shiao, B.-Y. Liao, M. Long, and H.-T. Yu (2008)
Genetics
178, 1683-1691
| Abstract »
| Full Text »
| PDF »
- Qualifying the relationship between sequence conservation and molecular function.
- G. M. Cooper and C. D. Brown (2008)
Genome Res.
18, 201-205
| Abstract »
| Full Text »
| PDF »
- Gene number expansion and contraction in vertebrate genomes with respect to invertebrate genomes.
- A. Prachumwat and W.-H. Li (2008)
Genome Res.
18, 221-232
| Abstract »
| Full Text »
| PDF »
- A Botrytis cinerea Emopamil Binding Domain Protein, Required for Full Virulence, Belongs to a Eukaryotic Superfamily Which Has Expanded in Euascomycetes.
- A. Gioti, J. M. Pradier, E. Fournier, P. Le Pecheur, C. Giraud, D. Debieu, J. Bach, P. Leroux, and C. Levis (2008)
Eukaryot. Cell
7, 368-378
| Abstract »
| Full Text »
| PDF »
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- T. Matsuo (2008)
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178, 1061-1072
| Abstract »
| Full Text »
| PDF »
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- T. Yuri, R. T. Kimball, E. L. Braun, and M. J. Braun (2008)
Mol. Biol. Evol.
25, 352-361
| Abstract »
| Full Text »
| PDF »
- Preferential protection of protein interaction network hubs in yeast: Evolved functionality of genetic redundancy.
- R. Kafri, O. Dahan, J. Levy, and Y. Pilpel (2008)
PNAS
105, 1243-1248
| Abstract »
| Full Text »
| PDF »
- MANTIS: a phylogenetic framework for multi-species genome comparisons.
- A. C. Tzika, R. Helaers, Y. Van de Peer, and M. C. Milinkovitch (2008)
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24, 151-157
| Abstract »
| Full Text »
| PDF »
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- G. Ding, Y. Sun, H. Li, Z. Wang, H. Fan, C. Wang, D. Yang, and Y. Li (2008)
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36, D255-D262
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| Full Text »
| PDF »
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- S. A. Rensing, D. Lang, A. D. Zimmer, A. Terry, A. Salamov, H. Shapiro, T. Nishiyama, P.-F. Perroud, E. A. Lindquist, Y. Kamisugi, et al. (2008)
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- K. Bismuth, S. Skuntz, J. H. Hallsson, E. Pak, A. S. Dutra, E. Steingrimsson, and H. Arnheiter (2008)
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| PDF »
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- D. R. Scannell and K. H. Wolfe (2008)
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18, 137-147
| Abstract »
| Full Text »
| PDF »
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- C. Rispe, M. Kutsukake, V. Doublet, S. Hudaverdian, F. Legeai, J.-C. Simon, D. Tagu, and T. Fukatsu (2008)
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| Full Text »
| PDF »
- A Genomic and Expression Compendium of the Expanded PEBP Gene Family from Maize.
- O. N. Danilevskaya, X. Meng, Z. Hou, E. V. Ananiev, and C. R. Simmons (2008)
Plant Physiology
146, 250-264
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- Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes.
- A. Heger and C. P. Ponting (2007)
Genome Res.
17, 1837-1849
| Abstract »
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- Accurate gene-tree reconstruction by learning gene- and species-specific substitution rates across multiple complete genomes.
- M. D. Rasmussen and M. Kellis (2007)
Genome Res.
17, 1932-1942
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