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Science 27 October 2000:
Vol. 290. no. 5492, pp. 799 - 801
DOI: 10.1126/science.290.5492.799
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Reports
Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei
Horacio O. de la ,
Iglesia,*
Jennifer Meyer,
Alan Carpino Jr.,
William
J. Schwartz
An unusual property of the circadian timekeeping systems
of animals is rhythm "splitting," in which a single daily period of
physical activity (usually measured as wheel running) dissociates into
two stably coupled components about 12 hours apart; this behavior has
been ascribed to a clock composed of two circadian oscillators cycling
in antiphase. We analyzed gene expression in the hypothalamic circadian
clock, the suprachiasmatic nucleus (SCN), of behaviorally "split"
hamsters housed in constant light. The results show that the two
oscillators underlying the split condition correspond to the left and
right sides of the bilaterally paired SCN.
Department of Neurology, University of Massachusetts Medical
School, 55 Lake Avenue North, Worcester, MA 01655, USA.
*
To whom correspondence should be addressed. E-mail:
hacho{at}bio.umass.edu
Read the Full Text
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