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Science 27 October 2000:
Vol. 290. no. 5492, pp. 754 - 758
DOI: 10.1126/science.290.5492.754
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Review

Actin-Based Plasticity in Dendritic Spines

Andrew Matus

The central nervous system functions primarily to convert patterns of activity in sensory receptors into patterns of muscle activity that constitute appropriate behavior. At the anatomical level this requires two complementary processes: a set of genetically encoded rules for building the basic network of connections, and a mechanism for subsequently fine tuning these connections on the basis of experience. Identifying the locus and mechanism of these structural changes has long been among neurobiology's major objectives. Evidence has accumulated implicating a particular class of contacts, excitatory synapses made onto dendritic spines, as the sites where connective plasticity occurs. New developments in light microscopy allow changes in spine morphology to be directly visualized in living neurons and suggest that a common mechanism, based on dynamic actin filaments, is involved in both the formation of dendritic spines during development and their structural plasticity at mature synapses.

Friedrich Miescher Institute, Maulbeerstrasse 66, 4058 Basel, Switzerland.
E-mail: matus{at}fmi.ch

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Matrix Metalloproteinase-9 Undergoes Expression and Activation during Dendritic Remodeling in Adult Hippocampus.
A. Szklarczyk, J. Lapinska, M. Rylski, R. D. G. McKay, and L. Kaczmarek (2002)
J. Neurosci. 22, 920-930
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Aluminum-Induced Dendritic Pathology Revisited: Cytochemical and Electron Microscopic Studies of Rabbit Cortical Pyramidal Neurons.
M. S. Forbes, O. Ghribi, M. M. Herman, and J. Savory (2002)
Ann. Clin. Lab. Sci. 32, 75-86
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Regulation of NMDA Receptor Activity by F-Actin and Myosin Light Chain Kinase.
S. Lei, E. Czerwinska, W. Czerwinski, M. P. Walsh, and J. F. MacDonald (2001)
J. Neurosci. 21, 8464-8472
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N-Methyl-D-aspartate-induced alpha -Amino-3-hydroxy-5-methyl-4-isoxazoleproprionic Acid (AMPA) Receptor Down-regulation Involves Interaction of the Carboxyl Terminus of GluR2/3 with Pick1. LIGAND-BINDING STUDIES USING Sindbis VECTORS CARRYING AMPA RECEPTOR DECOYS.
Y. Iwakura, T. Nagano, M. Kawamura, H. Horikawa, K. Ibaraki, N. Takei, and H. Nawa (2001)
J. Biol. Chem. 276, 40025-40032
   Abstract »    Full Text »    PDF »
Dendrites.
Y.-N. Jan and L. Y. Jan (2001)
Genes & Dev. 15, 2627-2641
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Remodeling of Synaptic Membranes after Induction of Long-Term Potentiation.
N. Toni, P.-A. Buchs, I. Nikonenko, P. Povilaitite, L. Parisi, and D. Muller (2001)
J. Neurosci. 21, 6245-6251
   Abstract »    Full Text »    PDF »
Associative Learning Elicits the Formation of Multiple-Synapse Boutons.
Y. Geinisman, R. W. Berry, J. F. Disterhoft, J. M. Power, and E. A. Van der Zee (2001)
J. Neurosci. 21, 5568-5573
   Abstract »    Full Text »    PDF »
Identification of Genes Expressed in the Amygdala During the Formation of Fear Memory.
O. Stork, S. Stork, H.-C. Pape, and K. Obata (2001)
Learn. Mem. 8, 209-219
   Abstract »    Full Text »    PDF »
Cytoskeletal microdifferentiation: A mechanism for organizing morphological plasticity in dendrites.
S. Kaech, H. Parmar, M. Roelandse, C. Bornmann, and A. Matus (2001)
PNAS 98, 7086-7092
   Abstract »    Full Text »    PDF »
Diversity and Dynamics of Dendritic Signaling.
M. Häusser, N. Spruston, and G. J. Stuart (2000)
Science 290, 739-744
   Abstract »    Full Text »


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