Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Michael Häusser,1*Nelson Spruston,2Greg J. Stuart3
Communication between neurons in the brain occurs primarily
through synapses made onto elaborate treelike structures calleddendrites. New electrical and optical recording techniques haveled to
tremendous advances in our understanding of how dendritescontribute to
neuronal computation in the mammalian brain. Thevaried morphology and
electrical and chemical properties of dendritesenable a spectrum of
local and long-range signaling, definingthe input-output relationship
of neurons and the rules for inductionof synaptic plasticity. In this
way, diversity in dendritic signalingallows individual neurons to
carry out specialized functions withintheir respective networks.
1 Department of Physiology, University College
London, Gower Street, London WC1E 6BT, UK.
2 Department of Neurobiology and Physiology,
Institute for Neuroscience, Northwestern University, Evanston, IL
60208, USA.
3 Division of Neuroscience, John Curtin
School of Medical Research, Australian National University, Canberra,
ACT 0200, Australia.
*
To whom correspondence should be addressed. E-mail:
m.hausser{at}ucl.ac.uk
The editors suggest the following Related Resources on Science sites:
In Science Magazine
NEWS FOCUS
Laura Helmuth (27 October 2000) Science290 (5492), 698.
[DOI: 10.1126/science.290.5492.698] |Summary »|Full Text »
EDITORIAL
Donald Kennedy (27 October 2000) Science290 (5492), 709.
[DOI: 10.1126/science.290.5492.709] |Summary »
INTRODUCTION TO SPECIAL ISSUE
Peter Stern and Jean Marx (27 October 2000) Science290 (5492), 735.
[DOI: 10.1126/science.290.5492.735] |Summary »
NEWS
Marcia Barinaga (27 October 2000) Science290 (5492), 736.
[DOI: 10.1126/science.290.5492.736] |Summary »|Full Text »
NEWS
Marcia Barinaga (27 October 2000) Science290 (5492), 737.
[DOI: 10.1126/science.290.5492.737] |Summary »|Full Text »
REVIEW
Idan Segev and Michael London (27 October 2000) Science290 (5492), 744.
[DOI: 10.1126/science.290.5492.744] |Abstract »|Full Text »|PDF »
REVIEW
Mary B. Kennedy (27 October 2000) Science290 (5492), 750.
[DOI: 10.1126/science.290.5492.750] |Abstract »|Full Text »|PDF »
REVIEW
Andrew Matus (27 October 2000) Science290 (5492), 754.
[DOI: 10.1126/science.290.5492.754] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Morphological and Physiological Characteristics of the Serotonin-Immunoreactive Neuron in the Antennal Lobe of the Male Oriental Tobacco Budworm, Helicoverpa assulta.
The Electrotonic Structure of Pyramidal Neurons Contributing to Prefrontal Cortical Circuits in Macaque Monkeys Is Significantly Altered in Aging.
D. Kabaso, P. J. Coskren, B. I. Henry, P. R. Hof, and S. L. Wearne (2009)
Cereb Cortex
|Abstract »|Full Text »|PDF »
Associative Learning on a Continuum in Evolved Dynamical Neural Networks.
E. Izquierdo, I. Harvey, and R. D. Beer (2008)
Adaptive Behavior
16, 361-384
|Abstract »|PDF »
Dendrite Elongation and Dendritic Branching Are Affected Separately by Different Forms of Intrinsic Motoneuron Excitability.
C. Duch, F. Vonhoff, and S. Ryglewski (2008)
J Neurophysiol
100, 2525-2536
|Abstract »|Full Text »|PDF »
Differential dendritic Ca2+ signalling in young and mature hippocampal granule cells.
G. Stocca, C. Schmidt-Hieber, and J. Bischofberger (2008)
J. Physiol.
586, 3795-3811
|Abstract »|Full Text »|PDF »
Intracellular Recordings From Combination-Sensitive Neurons in the Inferior Colliculus.
D. C. Peterson, S. Voytenko, D. Gans, A. Galazyuk, and J. Wenstrup (2008)
J Neurophysiol
100, 629-645
|Abstract »|Full Text »|PDF »
Summation of Excitatory and Inhibitory Synaptic Inputs by Motoneurons With Highly Active Dendrites.
A. S. Hyngstrom, M. D. Johnson, and C. J. Heckman (2008)
J Neurophysiol
99, 1643-1652
|Abstract »|Full Text »|PDF »
Dendritic Excitability and Synaptic Plasticity.
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser (2008)
Physiol Rev
88, 769-840
|Abstract »|Full Text »|PDF »
Electric Fields Due to Synaptic Currents Sharpen Excitatory Transmission.
S. Sylantyev, L. P. Savtchenko, Y.-P. Niu, A. I. Ivanov, T. P. Jensen, D. M. Kullmann, M.-Y. Xiao, and D. A. Rusakov (2008)
Science
319, 1845-1849
|Abstract »|Full Text »|PDF »
Ion binding in the Open HCN Pacemaker Channel Pore: Fast Mechanisms to Shape "Slow" Channels.
Sustained Rhythmic Activity in Gap-Junctionally Coupled Networks of Model Neurons Depends on the Diameter of Coupled Dendrites.
J. Gansert, J. Golowasch, and F. Nadim (2007)
J Neurophysiol
98, 3450-3460
|Abstract »|Full Text »|PDF »
Voltage and calcium transients in basal dendrites of the rat prefrontal cortex.
B. A. Milojkovic, W.-L. Zhou, and S. D. Antic (2007)
J. Physiol.
585, 447-468
|Abstract »|Full Text »|PDF »
Dendrite-to-Soma Input/Output Function of Continuous Time-Varying Signals in Hippocampal CA1 Pyramidal Neurons.
E. P. Cook, J. A. Guest, Y. Liang, N. Y. Masse, and C. M. Colbert (2007)
J Neurophysiol
98, 2943-2955
|Abstract »|Full Text »|PDF »
Regulation of NaV1.2 Channels by Brain-Derived Neurotrophic Factor, TrkB, and Associated Fyn Kinase.
M. Ahn, D. Beacham, R. E. Westenbroek, T. Scheuer, and W. A. Catterall (2007)
J. Neurosci.
27, 11533-11542
|Abstract »|Full Text »|PDF »
Quantal and Nonquantal Transmission in Calyx-Bearing Fibers of the Turtle Posterior Crista.
J. C. Holt, S. Chatlani, A. Lysakowski, and J. M. Goldberg (2007)
J Neurophysiol
98, 1083-1101
|Abstract »|Full Text »|PDF »
Weak action potential backpropagation is associated with high-frequency axonal firing capability in principal neurons of the gerbil medial superior olive.
L. L. Scott, T. A. Hage, and N. L. Golding (2007)
J. Physiol.
583, 647-661
|Abstract »|Full Text »|PDF »
Targeted dendrotomy reveals active and passive contributions of the dendritic tree to synaptic integration and neuronal output.
Differential Intrinsic Response Dynamics Determine Synaptic Signal Processing in Frog Vestibular Neurons.
M. Beraneck, S. Pfanzelt, I. Vassias, M. Rohregger, N. Vibert, P.-P. Vidal, L. E. Moore, and H. Straka (2007)
J. Neurosci.
27, 4283-4296
|Abstract »|Full Text »|PDF »
A model biological neural network: the cephalopod vestibular system.
Physiologic Regulation of a Tetrodotoxin-Sensitive Sodium Influx That Mediates a Slow Afterdepolarization Potential in Gonadotropin-Releasing Hormone Neurons: Possible Implications for the Central Regulation of Fertility..
Controlling Synaptic Input Patterns In Vitro by Dynamic Photo Stimulation.
C. Boucsein, M. Nawrot, S. Rotter, A. Aertsen, and D. Heck (2005)
J Neurophysiol
94, 2948-2958
|Abstract »|Full Text »|PDF »
Dendritic Excitability of Mouse Frontal Cortex Pyramidal Neurons Is Shaped by the Interaction among HCN, Kir2, and Kleak Channels.
M. Day, D. B. Carr, S. Ulrich, E. Ilijic, T. Tkatch, and D. J. Surmeier (2005)
J. Neurosci.
25, 8776-8787
|Abstract »|Full Text »|PDF »
Ionic Mechanisms Underlying Autonomous Action Potential Generation in the Somata and Dendrites of GABAergic Substantia Nigra Pars Reticulata Neurons In Vitro.
Constitutively Active Cytoplasmic c-Jun N-Terminal Kinase 1 Is a Dominant Regulator of Dendritic Architecture: Role of Microtubule-Associated Protein 2 as an Effector.
B. Bjorkblom, N. Ostman, V. Hongisto, V. Komarovski, J.-J. Filen, T. A. Nyman, T. Kallunki, M. J. Courtney, and E. T. Coffey (2005)
J. Neurosci.
25, 6350-6361
|Abstract »|Full Text »|PDF »
NMDA Receptor Subunit-Dependent [Ca2+] Signaling in Individual Hippocampal Dendritic Spines.
Dopamine D1/D5 Receptor Modulates State-Dependent Switching of Soma-Dendritic Ca2+ Potentials via Differential Protein Kinase A and C Activation in Rat Prefrontal Cortical Neurons.
Submillisecond Precision of the Input-Output Transformation Function Mediated by Fast Sodium Dendritic Spikes in Basal Dendrites of CA1 Pyramidal Neurons.
Multiple Modes of Action Potential Initiation and Propagation in Mitral Cell Primary Dendrite.
W. R. Chen, G. Y. Shen, G. M. Shepherd, M. L. Hines, and J. Midtgaard (2002)
J Neurophysiol
88, 2755-2764
|Abstract »|Full Text »|PDF »
The AMPA Receptor Subunit GluR1 Regulates Dendritic Architecture of Motor Neurons.
F. M. Inglis, R. Crockett, S. Korada, W. C. Abraham, M. Hollmann, and R. G. Kalb (2002)
J. Neurosci.
22, 8042-8051
|Abstract »|Full Text »|PDF »
Cortical region interactions and the functional role of apical dendrites..
M. W. Spratling (2002)
Behav Cogn Neurosci Rev
1, 219-228
|Abstract »|PDF »
Signaling of Layer 1 and Whisker-Evoked Ca2+ and Na+ Action Potentials in Distal and Terminal Dendrites of Rat Neocortical Pyramidal Neurons In Vitro and In Vivo.