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Science 27 October 2000:
Vol. 290. no. 5492, pp. 739 - 744
DOI: 10.1126/science.290.5492.739

Review

Diversity and Dynamics of Dendritic Signaling

Michael Häusser,1* Nelson Spruston,2 Greg J. Stuart3

Communication between neurons in the brain occurs primarily through synapses made onto elaborate treelike structures called dendrites. New electrical and optical recording techniques have led to tremendous advances in our understanding of how dendrites contribute to neuronal computation in the mammalian brain. The varied morphology and electrical and chemical properties of dendrites enable a spectrum of local and long-range signaling, defining the input-output relationship of neurons and the rules for induction of synaptic plasticity. In this way, diversity in dendritic signaling allows individual neurons to carry out specialized functions within their respective networks.

1 Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK.
2 Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, IL 60208, USA.
3 Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.
*   To whom correspondence should be addressed. E-mail: m.hausser{at}ucl.ac.uk


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