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With the detailed description and analysis of several inhibitory
receptor systems on lymphoid and myeloid cells, a centralparadigm has
emerged in which the pairing of activation and inhibitionis necessary
to initiate, amplify, and then terminate immune responses.In some
cases, the activating and inhibitory receptors recognizesimilar
ligands, and the net outcome is determined by the relativestrength of
these opposing signals. The importance of this modulationis
demonstrated by the sometimes fatal autoimmune disorders observedin
mice with targeted disruption of inhibitory receptors. Thesignificance
of these receptors is further evidenced by the conservationof
immunoreceptor tyrosine-based inhibitory motifs during theirevolution.
1 Laboratory of Molecular Genetics and
Immunology, Rockefeller University, New York, NY 10021, USA.
2 Department of Microbiology and Immunology and
Cancer Research Institute, University of California, San Francisco, CA
94143, USA.
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Benedict Seddon, Giuseppe Legname, Peter Tomlinson, and Rose Zamoyska (6 October 2000) Science290 (5489), 127.
[DOI: 10.1126/science.290.5489.127] |Abstract »|Full Text »|PDF »
INTRODUCTION TO SPECIAL ISSUE
Stephen Simpson, Stella M. Hurtley, and and Jean Marx (6 October 2000) Science290 (5489), 79.
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NEWS
Michael Hagmann (6 October 2000) Science290 (5489), 80.
[DOI: 10.1126/science.290.5489.80] |Summary »|Full Text »
NEWS
Michael Hagmann (6 October 2000) Science290 (5489), 82.
[DOI: 10.1126/science.290.5489.82] |Summary »|Full Text »
REVIEW
Sidonia Fagarasan and Tasuku Honjo (6 October 2000) Science290 (5489), 89.
[DOI: 10.1126/science.290.5489.89] |Abstract »|Full Text »|PDF »
VIEWPOINT
Antonio Lanzavecchia and Federica Sallusto (6 October 2000) Science290 (5489), 92.
[DOI: 10.1126/science.290.5489.92] |Abstract »|Full Text »|PDF »
REVIEW
Adrian Hayday and Joanne L. Viney (6 October 2000) Science290 (5489), 97.
[DOI: 10.1126/science.290.5489.97] |Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3.
G. Penna, A. Roncari, S. Amuchastegui, K. C. Daniel, E. Berti, M. Colonna, and L. Adorini (2005)
Blood
106, 3490-3497
|Abstract »|Full Text »|PDF »
Fc{gamma}RIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.
H. Kono, C. Kyogoku, T. Suzuki, N. Tsuchiya, H. Honda, K. Yamamoto, K. Tokunaga, and Z.-I. Honda (2005)
Hum. Mol. Genet.
14, 2881-2892
|Abstract »|Full Text »|PDF »
Down-Regulation of Basophil Function by Human CD200 and Human Herpesvirus-8 CD200.
I. Shiratori, M. Yamaguchi, M. Suzukawa, K. Yamamoto, L. L. Lanier, T. Saito, and H. Arase (2005)
J. Immunol.
175, 4441-4449
|Abstract »|Full Text »|PDF »
Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.
A. Kumanogoh, T. Shikina, C. Watanabe, N. Takegahara, K. Suzuki, M. Yamamoto, H. Takamatsu, D. V. R. Prasad, M. Mizui, T. Toyofuku, et al. (2005)
Int. Immunol.
17, 1277-1282
|Abstract »|Full Text »|PDF »
NK Cells Play a Critical Role in the Regulation of Class I-Deficient Hemopoietic Stem Cell Engraftment: Evidence for NK Tolerance Correlates with Receptor Editing.
Y. Huang, F. Rezzoug, H. Xu, P. M. Chilton, C. L. Schanie, I. Fugier-Vivier, and S. T. Ildstad (2005)
J. Immunol.
175, 3753-3761
|Abstract »|Full Text »|PDF »
Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44.
NKG2D-independent suppression of T cell proliferation by H60 and MICA.
A. K. Kriegeskorte, F. E. Gebhardt, S. Porcellini, M. Schiemann, C. Stemberger, T. J. Franz, K. M. Huster, L. N. Carayannopoulos, W. M. Yokoyama, M. Colonna, et al. (2005)
PNAS
102, 11805-11810
|Abstract »|Full Text »|PDF »
Signal Regulatory Protein {alpha} Ligation Induces Macrophage Nitric Oxide Production through JAK/STAT- and Phosphatidylinositol 3-Kinase/Rac1/NAPDH Oxidase/H2O2-Dependent Pathways.
J. Alblas, H. Honing, C. Renardel de Lavalette, M. H. Brown, C. D. Dijkstra, and T. K. van den Berg (2005)
Mol. Cell. Biol.
25, 7181-7192
|Abstract »|Full Text »|PDF »
Failed Up-Regulation of the Inhibitory IgG Fc Receptor Fc{gamma}RIIB on Germinal Center B Cells in Autoimmune-Prone Mice Is Not Associated with Deletion Polymorphisms in the Promoter Region of the Fc{gamma}RIIB Gene.
