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Science 15 September 2000:
Vol. 289. no. 5486, pp. 1946 - 1949
DOI: 10.1126/science.289.5486.1946
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Reports

Interhemispheric Asymmetries of the Modular Structure in Human Temporal Cortex

Ralf A. W. Galuske,1* Wolfgang Schlote,2 Hansjürgen Bratzke,3 Wolf Singer1

Language-relevant processing of auditory signals is lateralized and involves the posterior part of Brodmann area 22. We found that the functional lateralization in this area was accompanied by interhemispheric differences in the organization of the intrinsic microcircuitry. Neuronal tract tracing revealed a modular network of long-range intrinsic connections linking regularly spaced clusters of neurons. Although the cluster diameter was similar in both hemispheres, their spacing was about 20 percent larger in the left hemisphere. Assuming similar relations between functional and anatomical architecture as in visual cortex, the present data suggest that more functionally distinct columnar systems are included per surface unit in the left than in the right area 22.

1 Department of Neurophysiology, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt a.M., Germany.
2 Neurological Institute (Edinger Institute), University of Frankfurt Medical School, Deutschordenstrasse 46, 60528 Frankfurt a.M., Germany.
3 Institute of Forensic Medicine, University of Frankfurt Medical School, Kennedyallee 104, 60596 Frankfurt a.M., Germany.
*   To whom correspondence should be addressed: E-mail: galuske{at}mpih-frankfurt.mpg.de

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