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Science 1 September 2000:
Vol. 289. no. 5484, pp. 1564 - 1566
DOI: 10.1126/science.289.5484.1564
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Reports
Generation of G-to-A and C-to-U Changes in HIV-1 Transcripts by RNA Editing
K. Bourara,
S. Litvak,
A. Araya*
RNA editing involves posttranscriptional alterations of messenger
RNA (mRNA) sequences modifying the information content encoded by the
genetic message. Here, it is shown that, in chronically infected H9
cells, human immunodeficiency virus-type 1 (HIV-1) mRNAs undergo
guanine-to-adenine (G-to-A) and cytosine-to-uracil (C-to-U) changes.
G-to-A modification in the untranslated region of exon 1 was present
only in spliced HIV-1 mRNAs. The creation of stop codons in HIV-1 mRNAs
may function to control the translation of viral proteins, such as
viral protein R, that are involved in the regulation of HIV-1
expression and the survival of chronically infected cells.
Laboratoire de Réplication et Expression des Génomes
Eucaryotes et Rétroviraux, UMR 5097, CNRS-Université Victor Segalen-Bordeaux 2, and IFR 66 Pathologies Infectieuses, 146 rue Léo Saignat, 33076 Bordeaux
Cedex, France.
*
To whom correspondence should be addressed. E-mail:
Alexandre.Araya{at}reger.u-bordeaux2.fr
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