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Osteoporosis, a disease endemic in Western society,
typically reflects an imbalance in skeletal turnover so that bone
resorptionexceeds bone formation. Bone resorption is the unique
functionof the osteoclast, and anti-osteoporosis therapy to date has
targetedthis cell. The osteoclast is a specialized macrophage
polykaryonwhose differentiation is principally regulated by macrophage
colony-stimulatingfactor, RANK ligand, and osteoprotegerin. Reflecting
integrin-mediatedsignals, the osteoclast develops a specialized
cytoskeleton thatpermits it to establish an isolated microenvironment
between itselfand bone, wherein matrix degradation occurs by a process
involvingproton transport. Osteopetrotic mutants have provided a
wealthof information about the genes that regulate the differentiationof osteoclasts and their capacity to resorb bone.
Department of Pathology, Washington University School of
Medicine, Barnes-Jewish Hospital North, Mailstop 90-31-649, 216 South
Kingshighway, St. Louis, MO 63110, USA. E-mail:
teitelbs{at}medicine.wustl.edu
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Paula Kiberstis, Orla Smith, and Colin Norman (1 September 2000) Science289 (5484), 1497.
[DOI: 10.1126/science.289.5484.1497] |Summary »
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Nuclear Factor of Activated T Cells c1 Induces Osteoclast-associated Receptor Gene Expression during Tumor Necrosis Factor-related Activation-induced Cytokine-mediated Osteoclastogenesis.
K. Kim, J. H. Kim, J. Lee, H.-M. Jin, S.-H. Lee, D. E. Fisher, H. Kook, K. K. Kim, Y. Choi, and N. Kim (2005)
J. Biol. Chem.
280, 35209-35216
|Abstract »|Full Text »|PDF »
Transforming Growth Factor-{beta}1 to the Bone.
K. Janssens, P. ten Dijke, S. Janssens, and W. Van Hul (2005)
Endocr. Rev.
26, 743-774
|Abstract »|Full Text »|PDF »
Physical and Functional Association of c-Src and Adhesion and Degranulation Promoting Adaptor Protein (ADAP) in Osteoclastogenesis in Vitro.
S. Koga, K. Yogo, K. Yoshikawa, H. Samori, M. Goto, T. Uchida, N. Ishida, and T. Takeya (2005)
J. Biol. Chem.
280, 31564-31571
|Abstract »|Full Text »|PDF »
Osthole-Mediated Cell Differentiation through Bone Morphogenetic Protein-2/p38 and Extracellular Signal-Regulated Kinase 1/2 Pathway in Human Osteoblast Cells.
P.-L. Kuo, Y.-L. Hsu, C.-H. Chang, and J.-K. Chang (2005)
J. Pharmacol. Exp. Ther.
314, 1290-1299
|Abstract »|Full Text »|PDF »
{micro}-Calpain Regulates Receptor Activator of NF-{kappa}B Ligand (RANKL)-supported Osteoclastogenesis via NF-{kappa}B Activation in RAW 264.7 Cells.
F. Y.-I. Lee, D.-W. Kim, J. A. Karmin, D. Hong, S.-S. Chang, M. Fujisawa, H. Takayanagi, L. U. Bigliani, T. A. Blaine, and H.-J. Lee (2005)
J. Biol. Chem.
280, 29929-29936
|Abstract »|Full Text »|PDF »
Bisphosphonates in Orthopaedic Surgery.
C. D. Morris and T. A. Einhorn (2005)
J. Bone Joint Surg. Am.
87, 1609-1618
|Abstract »|Full Text »|PDF »
Homeostatic Role of Interferons Conferred by Inhibition of IL-1-Mediated Inflammation and Tissue Destruction.
X. Hu, H. H. Ho, O. Lou, C. Hidaka, and L. B. Ivashkiv (2005)
J. Immunol.
175, 131-138
|Abstract »|Full Text »|PDF »
Rab3D Regulates a Novel Vesicular Trafficking Pathway That Is Required for Osteoclastic Bone Resorption.
N. J. Pavlos, J. Xu, D. Riedel, J. S. G. Yeoh, S. L. Teitelbaum, J. M. Papadimitriou, R. Jahn, F. P. Ross, and M. H. Zheng (2005)
Mol. Cell. Biol.
25, 5253-5269
|Abstract »|Full Text »|PDF »
Potassium Channel-blockers as Therapeutic Agents to Interfere with Bone Resorption of Periodontal Disease.
P. Valverde, T. Kawai, and M.A. Taubman (2005)
Journal of Dental Research
84, 488-499
|Abstract »|Full Text »|PDF »
Evolution and modulation of age-related medial elastocalcinosis: Impact on large artery stiffness and isolated systolic hypertension.
H. H. Dao, R. Essalihi, C. Bouvet, and P. Moreau (2005)
Cardiovasc Res
66, 307-317
|Abstract »|Full Text »|PDF »
Reactive Oxygen Species Stimulates Receptor Activator of NF-{kappa}B Ligand Expression in Osteoblast.
X.-c. Bai, D. Lu, A.-l. Liu, Z.-m. Zhang, X.-m. Li, Z.-p. Zou, W.-s. Zeng, B.-l. Cheng, and S.-q. Luo (2005)
J. Biol. Chem.
280, 17497-17506
|Abstract »|Full Text »|PDF »
Osteoporosis and Integrins.
S. L. Teitelbaum (2005)
J. Clin. Endocrinol. Metab.
90, 2466-2468
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Effect of L-000845704, an {alpha}V{beta}3 Integrin Antagonist, on Markers of Bone Turnover and Bone Mineral Density in Postmenopausal Osteoporotic Women.
M. G. Murphy, K. Cerchio, S. A. Stoch, K. Gottesdiener, M. Wu, R. Recker, and for the L-000845704 Study Group (2005)
J. Clin. Endocrinol. Metab.
90, 2022-2028
|Abstract »|Full Text »|PDF »
Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Inhibits Tumor Necrosis Factor (TNF)-{alpha}-induced Osteoclast Differentiation by Down-regulation of Expression of TNF Receptors 1 and 2.
S. D. Yogesha, S. M. Khapli, and M. R. Wani (2005)
J. Biol. Chem.
280, 11759-11769
|Abstract »|Full Text »|PDF »
CD44 is a determinant of inflammatory bone loss.
S. Hayer, G. Steiner, B. Gortz, E. Reiter, M. Tohidast-Akrad, M. Amling, O. Hoffmann, K. Redlich, J. Zwerina, K. Skriner, et al. (2005)
J. Exp. Med.
201, 903-914
|Abstract »|Full Text »|PDF »
Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis.
C. E.T. da Costa, N. E. Annels, C. M.J.M. Faaij, R. G. Forsyth, P. C.W. Hogendoorn, and R. M. Egeler (2005)
J. Exp. Med.
201, 687-693
|Abstract »|Full Text »|PDF »
Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-{alpha}-induced genes in bone cells.
F. Shen, M. J. Ruddy, P. Plamondon, and S. L. Gaffen (2005)
J. Leukoc. Biol.
77, 388-399
|Abstract »|Full Text »|PDF »
Involvement of Calpain in Osteoclastic Bone Resorption.
M. Hayashi, Y. Koshihara, H. Ishibashi, S. Yamamoto, S. Tsubuki, T. C. Saido, S. Kawashima, and M. Inomata (2005)
J. Biochem.
137, 331-338
|Abstract »|Full Text »|PDF »
Bone Mineral Density During Total Contact Cast Immobilization for a Patient With Neuropathic (Charcot) Arthropathy.
M. K Hastings, D. R Sinacore, F. A Fielder, and J. E Johnson (2005)
Physical Therapy
85, 249-256
|Abstract »|Full Text »|PDF »
