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Science 25 August 2000:
Vol. 289. no. 5483, pp. 1357 - 1360
DOI: 10.1126/science.289.5483.1357
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Reports

PAX8-PPARgamma 1 Fusion Oncogene in Human Thyroid Carcinoma

Todd G. Kroll,1* Pasha Sarraf,2 Lorenza Pecciarini,1 Chang-Jie Chen,1 Elisabetta Mueller,2 Bruce M. Spiegelman,2 Jonathan A. Fletcher123*

Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not in carcinomas, the most common human cancers. Here, we report that t(2;3)(q13;p25), a translocation identified in a subset of human thyroid follicular carcinomas, results in fusion of the DNA binding domains of the thyroid transcription factor PAX8 to domains A to F of the peroxisome proliferator-activated receptor (PPAR) gamma 1. PAX8-PPARgamma 1 mRNA and protein were detected in 5 of 8 thyroid follicular carcinomas but not in 20 follicular adenomas, 10 papillary carcinomas, or 10 multinodular hyperplasias. PAX8-PPARgamma 1 inhibited thiazolidinedione-induced transactivation by PPARgamma 1 in a dominant negative manner. The experiments demonstrate an oncogenic role for PPARgamma and suggest that PAX8-PPARgamma 1 may be useful in the diagnosis and treatment of thyroid carcinoma.

1 Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA, and Harvard Medical School, Boston, MA 02115, USA.
2 Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
3 Departments of Pathology and Pediatric Oncology, Children's Hospital, Boston, MA 02115, USA.
*   To whom correspondence should be addressed. E-mail: tkroll{at}rics.bwh.harvard.edu; jfletcher{at}rics.bwh.harvard.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Expression and Localization of the Homeodomain-Containing Protein HEX in Human Thyroid Tumors.
A. V. D'Elia, G. Tell, D. Russo, F. Arturi, F. Puglisi, G. Manfioletti, V. Gattei, D. L. Mack, P. Cataldi, S. Filetti, et al. (2002)
J. Clin. Endocrinol. Metab. 87, 1376-1383
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-activated Receptor Modulators As Potential Chemopreventive Agents.
L. Kopelovich, J. R. Fay, R. I. Glazer, and J. A. Crowell (2002)
Mol. Cancer Ther. 1, 357-363
   Abstract »    Full Text »    PDF »
The RET/PTC Oncogene Is Frequently Activated in Oncocytic Thyroid Tumors (Hurthle Cell Adenomas and Carcinomas), but Not in Oncocytic Hyperplastic Lesions.
G. Chiappetta, P. Toti, F. Cetta, A. Giuliano, F. Pentimalli, I. Amendola, S. Lazzi, M. Monaco, L. Mazzuchelli, P. Tosi, et al. (2002)
J. Clin. Endocrinol. Metab. 87, 364-369
   Abstract »    Full Text »    PDF »
BRD4 Bromodomain Gene Rearrangement in Aggressive Carcinoma with Translocation t(15;19).
C. A. French, I. Miyoshi, J. C. Aster, I. Kubonishi, T. G. Kroll, P. Dal Cin, S. O. Vargas, A. R. Perez-Atayde, and J. A. Fletcher (2001)
Am. J. Pathol. 159, 1987-1992
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Allelotyping of Follicular Thyroid Carcinoma: Frequent Allelic Losses in Chromosome Arms 7q, 11p, and 22q.
Y. Kitamura, K. Shimizu, K. Ito, S. Tanaka, and M. Emi (2001)
J. Clin. Endocrinol. Metab. 86, 4268-4272
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Anticancer Effects of Thiazolidinediones Are Independent of Peroxisome Proliferator-activated Receptor {gamma} and Mediated by Inhibition of Translation Initiation.
S. S. Palakurthi, H. Aktas, L. M. Grubissich, R. M. Mortensen, and J. A. Halperin (2001)
Cancer Res. 61, 6213-6218
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Mutational Analysis of the Peroxisome Proliferator-activated Receptor {{gamma}} Gene in Human Malignancies.
T. Ikezoe, C. W. Miller, S. Kawano, A. Heaney, E. A. Williamson, J. Hisatake, E. Green, W. Hofmann, H. Taguchi, and H. P. Koeffle (2001)
Cancer Res. 61, 5307-5310
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The Paired Box Domain Gene PAX5 Is Fused to ETV6/TEL in an Acute Lymphoblastic Leukemia Case.
G. Cazzaniga, M. Daniotti, S. Tosi, G. Giudici, A. Aloisi, E. Pogliani, L. Kearney, and A. Biondi (2001)
Cancer Res. 61, 4666-4670
   Abstract »    Full Text »    PDF »
PPARgamma : a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth.
E. D. Rosen and B. M. Spiegelman (2001)
J. Biol. Chem. 276, 37731-37734
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