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The cytokine interleukin-10 (IL-10) has shown promise in clinical
trials for treatment of inflammatory bowel disease (IBD).Using two
mouse models, we show that the therapeutic dose of IL-10can be reduced
by localized delivery of a bacterium geneticallyengineered to secrete
the cytokine. Intragastric administrationof IL-10-secreting
Lactococcus lactis caused a 50% reduction incolitis in
mice treated with dextran sulfate sodium and preventedthe onset of
colitis in IL-10/ mice. This approach may lead to
better methods for cost-effectiveand long-term management of IBD in
humans.
1 Department of Molecular Biology, Ghent
University and Flanders Interuniversity Institute for Biotechnology,
K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
2 Department of Internal Medicine I, University of
Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.
*
To whom correspondence should be addressed. E-mail:
lothar.steidler{at}dmb.rug.ac.be
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Fergus Shanahan (25 August 2000) Science289 (5483), 1311.
[DOI: 10.1126/science.289.5483.1311] |Summary »|Full Text »
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