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Science 30 June 2000:
Vol. 288. no. 5475, pp. 2373 - 2376
DOI: 10.1126/science.288.5475.2373
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Reports

A Subset of Viral Transcripts Packaged Within Human Cytomegalovirus Particles

Wade A. Bresnahan, Thomas Shenk *

A human cytomegalovirus gene array was used to identify a previously unidentified class of viral transcripts. These transcripts, termed virion RNAs, were packaged within infectious virions and were delivered to the host cell on infection. This mechanism of herpesvirus gene expression allows for viral genes to be expressed within an infected cell immediately after virus entry and in the absence of transcription from the viral genome.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
*   To whom correspondence should be addressed. E-mail: tshenk{at}princeton.edu

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