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Science 23 June 2000:
Vol. 288. no. 5474, pp. 2205 - 2208
DOI: 10.1126/science.288.5474.2205
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Reports

A Metalloprotease Disintegrin That Controls Cell Migration in Caenorhabditis elegans

Kiyoji Nishiwaki, 1* Naoki Hisamoto, 2 Kunihiro Matsumoto 2

In Caenorhabditis elegans, the gonad acquires two U-shaped arms by the directed migration of its distal tip cells (DTCs) along the body wall basement membranes. Correct migration of DTCs requires the mig-17 gene, which encodes a member of the metalloprotease-disintegrin protein family. The MIG-17 protein is secreted from muscle cells of the body wall and localizes in the basement membranes of gonad. This localization is dependent on the disintegrin-like domain of MIG-17 and its catalytic activity. These results suggest that the MIG-17 metalloprotease directs migration of DTCs by remodeling the basement membrane.

1 PRESTO, Japan Science and Technology Corporation and Fundamental Research Laboratories, NEC Corporation, Miyukigaoka, Tsukuba 305-8501, Japan.
2 Department of Molecular Biology, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, Chikusa-ku, Nagoya 464-8602, Japan.
*   To whom correspondence should be addressed. E-mail address: nishiwak{at}frl.cl.nec.co.jp

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