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Science 2 June 2000:
Vol. 288. no. 5471, pp. 1635 - 1640
DOI: 10.1126/science.288.5471.1635
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Reports

The Genetic Program of Hematopoietic Stem Cells

Robert L. Phillips, 1 Robin E. Ernst, 1 Brian Brunk, 2 Natalia Ivanova, 1 Mark A. Mahan, 1 Julia K. Deanehan, 1 Kateri A. Moore, 1 G. Christian Overton, 2 Ihor R. Lemischka 1*

Blood cell production originates from a rare population of multipotent, self-renewing stem cells. A genome-wide gene expression analysis was performed in order to define regulatory pathways in stem cells as well as their global genetic program. Subtracted complementary DNA libraries from highly purified murine fetal liver stem cells were analyzed with bioinformatic and array hybridization strategies. A large percentage of the several thousand gene products that have been characterized correspond to previously undescribed molecules with properties suggestive of regulatory functions. The complete data, available in a biological process-oriented database, represent the molecular phenotype of the hematopoietic stem cell.

1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
2 Computational Biology and Informatics Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA.
*   To whom correspondence should be addressed. E-mail: ilemischka{at}molbio.princeton.edu

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Chipping away at stem cells.
V. T. Chu and F. H. Gage (2001)
PNAS 98, 7652-7653
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From the Cover: From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs.
A. V. Terskikh, M. C. Easterday, L. Li, L. Hood, H. I. Kornblum, D. H. Geschwind, and I. L. Weissman (2001)
PNAS 98, 7934-7939
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Highly abundant genes in the transcriptosome of human and baboon CD34 antigen-positive bone marrow cells.
I. Gomes, T. T. Sharma, N. Mahmud, J. D. Kapp, S. Edassery, N. Fulton, J. Liang, R. Hoffman, and C. A. Westbrook (2001)
Blood 98, 93-99
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Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner.
M. Majka, A. Janowska-Wieczorek, J. Ratajczak, K. Ehrenman, Z. Pietrzkowski, M. A. Kowalska, A. M. Gewirtz, S. G. Emerson, and M. Z. Ratajczak (2001)
Blood 97, 3075-3085
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Autocrine/Paracrine Mechanisms in Human Hematopoiesis.
A. Janowska-Wieczorek, M. Majka, J. Ratajczak, and M. Z. Ratajczak (2001)
Stem Cells 19, 99-107
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Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver.
H.-C. Hsu, H. Ema, M. Osawa, Y. Nakamura, T. Suda, and H. Nakauchi (2000)
Blood 96, 3757-3762
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Differentiating Embryonal Stem Cells Are a Rich Source of Haemopoietic Gene Products and Suggest Erythroid Preconditioning of Primitive Haemopoietic Stem Cells.
J. W. Baird, K. M. Ryan, I. Hayes, L. Hampson, C. M Heyworth, A. Clark, M. Wootton, J. D. Ansell, U. Menzel, N. Hole, et al. (2001)
J. Biol. Chem. 276, 9189-9198
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A Cofactor of tRNA Synthetase, p43, Is Secreted to Up-regulate Proinflammatory Genes.
Y.-G. Ko, H. Park, T. Kim, J.-W. Lee, S. G. Park, W. Seol, J. E. Kim, W.-H. Lee, S.-H. Kim, J.-E. Park, et al. (2001)
J. Biol. Chem. 276, 23028-23033
   Abstract »    Full Text »    PDF »


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