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Science 19 May 2000:
Vol. 288. no. 5469, pp. 1254 - 1256
DOI: 10.1126/science.288.5469.1254
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Reports

Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

Kimberly M. Huber, Matthew S. Kayser, Mark F. Bear *

A hippocampal pyramidal neuron receives more than 104 excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.

Howard Hughes Medical Institute and Department of Neuroscience, Brown University, Providence, RI 02912, USA.
*   To whom correspondence should be addressed. E-mail: mbear{at}brown.edu

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Hippocampal cGMP-Dependent Protein Kinase I Supports an Age- and Protein Synthesis-Dependent Component of Long-Term Potentiation But Is Not Essential for Spatial Reference and Contextual Memory.
T. Kleppisch, W. Wolfsgruber, S. Feil, R. Allmann, C. T. Wotjak, S. Goebbels, K.-A. Nave, F. Hofmann, and R. Feil (2003)
J. Neurosci. 23, 6005-6012
   Abstract »    Full Text »    PDF »
How does an axon grow?.
J. L. Goldberg (2003)
Genes & Dev. 17, 941-958
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Facilitation of dendritic mRNA transport by CPEB.
Y.-S. Huang, J. H. Carson, E. Barbarese, and J. D. Richter (2003)
Genes & Dev. 17, 638-653
   Abstract »    Full Text »    PDF »
Protein Synthesis Is Required for Synaptic Immunity to Depotentiation.
N. H. Woo and P. V. Nguyen (2003)
J. Neurosci. 23, 1125-1132
   Abstract »    Full Text »    PDF »
Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices.
G. Rammes, M. Palmer, M. Eder, H.-U. Dodt, W. Zieglgansberger, and G. L Collingridge (2003)
J. Physiol. 546, 455-460
   Abstract »    Full Text »    PDF »
Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation.
M. Qin, J. Kang, and C. B. Smith (2002)
PNAS 99, 15758-15763
   Abstract »    Full Text »    PDF »
A Receptor for Activated C Kinase Is Part of Messenger Ribonucleoprotein Complexes Associated with PolyA-mRNAs in Neurons.
F. Angenstein, A. M. Evans, R. E. Settlage, S. T. Moran, S.-C. Ling, A. Y. Klintsova, J. Shabanowitz, D. F. Hunt, and W. T. Greenough (2002)
J. Neurosci. 22, 8827-8837
   Abstract »    Full Text »    PDF »
The Group I Metabotropic Glutamate Receptor Agonist (S)-3,5-Dihydroxyphenylglycine Induces a Novel Form of Depotentiation in the CA1 Region of the Hippocampus.
W.-M. Zho, J.-L. You, C.-C. Huang, and K.-S. Hsu (2002)
J. Neurosci. 22, 8838-8849
   Abstract »    Full Text »    PDF »
Different Mechanisms for Loss and Recovery of Binocularity in the Visual Cortex.
D. S. Liao, A. F. Mower, R. L. Neve, C. Sato-Bigbee, and A. S. Ramoa (2002)
J. Neurosci. 22, 9015-9023
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The Postsynaptic Glutamate Receptor Subunit DGluR-IIA Mediates Long-Term Plasticity in Drosophila.
S. J. Sigrist, P. R. Thiel, D. F. Reiff, and C. M. Schuster (2002)
J. Neurosci. 22, 7362-7372
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Modulation of Presynaptic Calcium Transients by Metabotropic Glutamate Receptor Activation: A Differential Role in Acute Depression of Synaptic Transmission and Long-Term Depression.
G. C. Faas, H. Adwanikar, R. W. Gereau IV, and P. Saggau (2002)
J. Neurosci. 22, 6885-6890
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Group I Metabotropic Glutamate Receptor (mGluR)-Dependent Long-Term Depression Mediated via p38 Mitogen-Activated Protein Kinase Is Inhibited by Previous High-Frequency Stimulation and Activation of mGluRs and Protein Kinase C in the Rat Dentate Gyrus In Vitro.
A. M. Rush, J. Wu, M. J. Rowan, and R. Anwyl (2002)
J. Neurosci. 22, 6121-6128
   Abstract »    Full Text »    PDF »


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