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Science 12 May 2000:
Vol. 288. no. 5468, pp. 1062 - 1064
DOI: 10.1126/science.288.5468.1062
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Reports

A High-Affinity Iron Permease Essential for Candida albicans Virulence

Narendrakumar Ramanan, Yue Wang *

Microbial pathogens must compete with the iron-withholding defense systems of their host to acquire this essential nutrient. Here, two high-affinity iron permease genes, CaFTR1 and CaFTR2, were isolated. CaFTR1 expression was induced under iron-limited conditions and repressed when iron supply was sufficient, whereas the expression of CaFTR2 was regulated in a reversed manner. Mutants lacking CaFTR1 but not CaFTR2 exhibited a severe growth defect in iron-deficient medium and were unable to establish systemic infection in mice. Thus, CaFTR1-mediated iron-uptake mechanism constitutes a virulence factor of Candida albicans and may be a target for the development of anti-Candida therapies.

Microbial Collection and Screening Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609.
*   To whom correspondence should be addressed. E-mail: mcbwangy{at}imcb.nus.edu.sg

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