Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 May 2000:
Vol. 288. no. 5467, pp. 857 - 859
DOI: 10.1126/science.288.5467.857
Prev | Table of Contents | Next

Reports

Evidence for Brainstem Structures Participating in Oculomotor Integration

K. Nakamagoe, 12 Y. Iwamoto, 1 K. Yoshida 1*

The cerebellar flocculus has been implicated in vestibulo-oculomotor control. One major central input to this structure originates from brainstem cells in the paramedian tract (PMT), whose function is unknown. Here it is reported that PMT cells in the pons carry vestibular and eye movement signals and their pharmacological inactivation produces a leaky integrator combined with vestibular imbalance. The results suggest that PMT cells provide the cerebellum with sensory and motor signals that are essential for velocity-to-position integration, a common premotor process that is required in all motor systems.

1 Department of Physiology, Institute of Basic Medical Sciences, and
2 Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
*   To whom correspondence should be addressed. E-mail: kyoshida{at}md.tsukuba.ac.jp

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional brain imaging of peripheral and central vestibular disorders.
M. Dieterich and T. Brandt (2008)
Brain 131, 2538-2552
   Abstract »    Full Text »    PDF »
Neural Correlates of Forward and Inverse Models for Eye Movements: Evidence from Three-Dimensional Kinematics.
F. F. Ghasia, H. Meng, and D. E. Angelaki (2008)
J. Neurosci. 28, 5082-5087
   Abstract »    Full Text »    PDF »
Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus.
K. Hufner, T. Stephan, R. Kalla, A. Deutschlander, J. Wagner, M. Holtmannspotter, G. Schulte-Altedorneburg, M. Strupp, T. Brandt, and S. Glasauer (2007)
Neurology 69, 1128-1135
   Abstract »    Full Text »    PDF »
4-Aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus.
R. Kalla, S. Glasauer, U. Buttner, T. Brandt, and M. Strupp (2007)
Brain 130, 2441-2451
   Abstract »    Full Text »    PDF »
Impaired ipsilateral smooth pursuit and gaze-evoked nystagmus in paramedian pontine lesion.
B. -Y. Ahn, K. -D. Choi, J. S. Kim, K. -P. Park, J. H. Bae, and T. -H. Lee (2007)
Neurology 68, 1436
   Full Text »    PDF »
Patterns of ocular oscillation in oculopalatal tremor: Imaging correlations.
J. S. Kim, S. Y. Moon, K. -D. Choi, J. -H. Kim, and J. A. Sharpe (2007)
Neurology 68, 1128-1135
   Abstract »    Full Text »    PDF »
A Reevaluation of the Inverse Dynamic Model for Eye Movements.
A. M. Green, H. Meng, and D. E. Angelaki (2007)
J. Neurosci. 27, 1346-1355
   Abstract »    Full Text »    PDF »
Upward gaze-evoked nystagmus with organoarsenic poisoning.
K. Nakamagoe, K. Ishii, A. Tamaoka, and S. Shoji (2006)
Neurology 66, 131-132
   Abstract »    Full Text »    PDF »
Vertical nystagmus: clinical facts and hypotheses.
C. Pierrot-Deseilligny and D. Milea (2005)
Brain 128, 1237-1246
   Abstract »    Full Text »    PDF »
Vertical-torsional oscillations and dissociated bilateral horizontal gaze palsy in a patient with a pontine cavernous angioma.
N Washio, Y Suzuki, T Yamaki, M Kase, and K Ohtsuka (2005)
J. Neurol. Neurosurg. Psychiatry 76, 283-285
   Abstract »    Full Text »    PDF »
Vertical vestibular responses to head impulses are symmetric in downbeat nystagmus.
S. Glasauer, H. von Lindeiner, C. Siebold, and U. Buttner (2004)
Neurology 63, 621-625
   Abstract »    Full Text »    PDF »
Plasticity and tuning by visual feedback of the stability of a neural integrator.
G. Major, R. Baker, E. Aksay, B. Mensh, H. S. Seung, and D. W. Tank (2004)
PNAS 101, 7739-7744
   Abstract »    Full Text »    PDF »
A Recurrent Network Model of Somatosensory Parametric Working Memory in the Prefrontal Cortex.
P. Miller, C. D Brody, R. Romo, and X.-J. Wang (2003)
Cereb Cortex 13, 1208-1218
   Abstract »    Full Text »    PDF »
Gravity Modulates Listing's Plane Orientation During Both Pursuit and Saccades.
B. J.M. Hess and D. E. Angelaki (2003)
J Neurophysiol 90, 1340-1345
   Abstract »    Full Text »    PDF »
Three-Dimensional Eye Position and Slow Phase Velocity in Humans With Downbeat Nystagmus.
S. Glasauer, M. Hoshi, U. Kempermann, T. Eggert, and U. Buttner (2003)
J Neurophysiol 89, 338-354
   Abstract »    Full Text »    PDF »
Drug treatments for eye movement disorders.
R J Leigh and R L Tomsak (2003)
J. Neurol. Neurosurg. Psychiatry 74, 1-4
   Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)