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Science 28 April 2000: Vol. 288. no. 5466, pp. 682 - 685 DOI: 10.1126/science.288.5466.682
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Reports
Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats
Shin Yamazaki,
1*
Rika Numano,
2*
Michikazu Abe,
1*
Akiko Hida,
2
Ri-ichi Takahashi,
3
Masatsugu Ueda,
3
Gene D. Block,
1
Yoshiyuki Sakaki,
2
Michael Menaker,
1
Hajime Tei
2
In multicellular organisms, circadian oscillators are
organized into multitissue systems which function as biological clocks that regulate the activities of the organism in relation to
environmental cycles and provide an internal temporal framework. To
investigate the organization of a mammalian circadian system, we
constructed a transgenic rat line in which luciferase is rhythmically
expressed under the control of the mouse Per1 promoter.
Light emission from cultured suprachiasmatic nuclei (SCN) of these rats
was invariably and robustly rhythmic and persisted for up to 32 days in
vitro. Liver, lung, and skeletal muscle also expressed circadian
rhythms, which damped after two to seven cycles in vitro. In response
to advances and delays of the environmental light cycle, the circadian rhythm of light emission from the SCN shifted more rapidly than did the
rhythm of locomotor behavior or the rhythms in peripheral tissues. We
hypothesize that a self-sustained circadian pacemaker in the SCN
entrains circadian oscillators in the periphery to maintain adaptive
phase control, which is temporarily lost following large, abrupt shifts
in the environmental light cycle.
1 NSF Center for Biological Timing and Department of
Biology, University of Virginia, Charlottesville, VA 22903-2477, USA.
2 Human Genome Center, Institute of Medical Science,
University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
3 Y.S. New Technology Institute Inc., 519 Shimoishibashi, Ishibashi-machi, Tochigi, 329-0500, Japan.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
mm7e{at}virginia.edu (M.M.) or tei{at}ims.u-tokyo.ac.jp (H.T.).
Read the Full Text
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- Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles.
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PNAS
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- Calcium Dynamics and Circadian Rhythms in Suprachiasmatic Nucleus Neurons.
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Neuroscientist
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- Circadian and Light-Induced Transcription of Clock Gen
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