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Science 28 April 2000:
Vol. 288. no. 5466, pp. 678 - 682
DOI: 10.1126/science.288.5466.678
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Reports

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

Linda M. Brzustowicz, 12* Kathleen A. Hodgkinson, 3 Eva W. C. Chow, 34 William G. Honer, 5 Anne S. Bassett 34

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

1 Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA.
2 Department of Psychiatry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
3 Genetics Section, Schizophrenia Research Program, Centre for Addiction and Mental Health, Queen Street Division, and
4 Department of Psychiatry, University of Toronto, Toronto M6J 1H4, Canada.
5 Department of Psychiatry, University of British Columbia, Vancouver V6H 3Z6, Canada.
*   To whom correspondence should be addressed. E-mail: brzustowicz{at}axon.rutgers.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)