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Science 28 April 2000:
Vol. 288. no. 5466, pp. 675 - 678
DOI: 10.1126/science.288.5466.675
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Reports

Control of Homeostasis of CD8+ Memory T Cells by Opposing Cytokines

Chia Chi Ku, 12* Masaaki Murakami, 1* Akemi Sakamoto, 1 John Kappler, 1245 Philippa Marrack 1235dagger

Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

1 Howard Hughes Medical Institute, Department of Medicine, National Jewish Medical and Research Center and Departments of
2 Immunology,
3 Biochemistry and Molecular Biology,
4 Pharmacology, and
5 Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA.
*   These authors contributed equally to the work.

dagger    To whom correspondence should be addressed. E-mail: marrackp{at}njc.org

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Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.
R. Zeng, R. Spolski, S. E. Finkelstein, S. Oh, P. E. Kovanen, C. S. Hinrichs, C. A. Pise-Masison, M. F. Radonovich, J. N. Brady, N. P. Restifo, et al. (2005)
J. Exp. Med. 201, 139-148
   Abstract »    Full Text »    PDF »
Role of Tumor Necrosis Factor Receptors in Regulating CD8 T-Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection.
M. Suresh, A. Singh, and C. Fischer (2005)
J. Virol. 79, 202-213
   Abstract »    Full Text »    PDF »
Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy.
D. J. Powell Jr, M. E. Dudley, P. F. Robbins, and S. A. Rosenberg (2005)
Blood 105, 241-250
   Abstract »    Full Text »    PDF »
Coordinated Expression of Ig-Like Inhibitory MHC Class I Receptors and Acquisition of Cytotoxic Function in Human CD8+ T Cells.
N. Anfossi, J.-M. Doisne, M.-A. Peyrat, S. Ugolini, O. Bonnaud, D. Bossy, V. Pitard, P. Merville, J.-F. Moreau, J.-F. Delfraissy, et al. (2004)
J. Immunol. 173, 7223-7229
   Abstract »    Full Text »    PDF »
The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing.
M. Conklyn, C. Andresen, P. Changelian, and E. Kudlacz (2004)
J. Leukoc. Biol. 76, 1248-1255
   Abstract »    Full Text »    PDF »
Evidence of a Novel IL-2/15R{beta}-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells.
D. Kamimura, N. Ueda, Y. Sawa, S. Hachida, T. Atsumi, T. Nakagawa, S.-i. Sawa, G.-H. Jin, H. Suzuki, K. Ishihara, et al. (2004)
J. Immunol. 173, 6041-6049
   Abstract »    Full Text »    PDF »
Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis.
M. Rifa'i, Y. Kawamoto, I. Nakashima, and H. Suzuki (2004)
J. Exp. Med. 200, 1123-1134
   Abstract »    Full Text »    PDF »
IL-15/IL-15R{alpha}-mediated avidity maturation of memory CD8+ T cells.
S. Oh, L. P. Perera, D. S. Burke, T. A. Waldmann, and J. A. Berzofsky (2004)
PNAS 101, 15154-15159
   Abstract »    Full Text »    PDF »
Characterization of the Systemic Loss of Dendritic Cells in Murine Lymph Nodes During Polymicrobial Sepsis.
P. A. Efron, A. Martins, D. Minnich, K. Tinsley, R. Ungaro, F. R. Bahjat, R. Hotchkiss, M. Clare-Salzler, and L. L. Moldawer (2004)
J. Immunol. 173, 3035-3043
   Abstract »    Full Text »    PDF »
Proliferation and Differentiation of CD8+ T Cells in the Absence of IL-2/15 Receptor {beta}-Chain Expression or STAT5 Activation.
R. M. Teague, R. M. Tempero, S. Thomas, K. Murali-Krishna, and B. H. Nelson (2004)
J. Immunol. 173, 3131-3139
   Abstract »    Full Text »    PDF »


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