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Science 21 April 2000:
Vol. 288. no. 5465, pp. 522 - 527
DOI: 10.1126/science.288.5465.522
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Reports

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

Shannon J. Turley, 1 Kayo Inaba, 2 Wendy S. Garrett, 1 Melanie Ebersold, 1 Julia Unternaehrer, 1 Ralph M. Steinman, 3 Ira Mellman 1*

Major histocompatibility complex class II (MHC II) molecules capture peptides within the endocytic pathway to generate T cell receptor (TCR) ligands. Immature dendritic cells (DCs) sequester intact antigens in lysosomes, processing and converting antigens into peptide-MHC II complexes upon induction of DC maturation. The complexes then accumulate in distinctive, nonlysosomal MHC II+ vesicles that appear to migrate to the cell surface. Although the vesicles exclude soluble lysosomal contents and antigen-processing machinery, many contain MHC I and B7 costimulatory molecules. After arrival at the cell surface, the MHC and costimulatory molecules remain clustered. Thus, transport of peptide-MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.

1 Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520-8002, USA.
2 Laboratory of Immunobiology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
3 Laboratory of Cellular Immunology and Physiology, Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA.
*   To whom correspondence should be addressed. E-mail: ira.mellman{at}yale.edu

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   Abstract »    PDF »
Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2.
C. J. Hertz, S. M. Kiertscher, P. J. Godowski, D. A. Bouis, M. V. Norgard, M. D. Roth, and R. L. Modlin (2001)
J. Immunol. 166, 2444-2450
   Abstract »    Full Text »    PDF »
Differentiation of T Regulatory Cells by Immature Dendritic Cells.
M.-G. Roncarolo, M. K. Levings, and C. Traversari (2001)
J. Exp. Med. 193, f5-f10
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Modulation of MHC class II transport and lysosome distribution by macrophage-colony stimulating factor in human dendritic cells derived from monocytes.
C Baron, G Raposo, S. Scholl, H Bausinger, D Tenza, A Bohbot, P Pouillart, B Goud, D Hanau, and J Salamero (2001)
J. Cell Sci. 114, 999-1010
   Abstract »    PDF »
Dendritic Cells, Infected with Vesicular Stomatitis Virus-Pseudotyped HIV-1, Present Viral Antigens to CD4+ and CD8+ T Cells from HIV-1-Infected Individuals.
A. Granelli-Piperno, L. Zhong, P. Haslett, J. Jacobson, and R. M. Steinman (2000)
J. Immunol. 165, 6620-6626
   Abstract »    Full Text »    PDF »
Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in the Presence of Lipopolysaccharide.
A. G. Castro, M. Neighbors, S. D. Hurst, F. Zonin, R. A. Silva, E. Murphy, Y.-J. Liu, and A. O'Garra (2000)
J. Exp. Med. 192, 1529-1534
   Abstract »    Full Text »    PDF »
Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells.
A. Lanzavecchia and F. Sallusto (2000)
Science 290, 92-97
   Abstract »    Full Text »
Exosome: from internal vesicle of the multivesicular body to intercellular signaling device.
K Denzer, M. Kleijmeer, H. Heijnen, W Stoorvogel, and H. Geuze (2000)
J. Cell Sci. 113, 3365-3374
   Abstract »    PDF »
Receptor Proximity, Not Intermolecular Orientation, Is Critical for Triggering T-cell Activation.
J. R. Cochran, T. O. Cameron, J. D. Stone, J. B. Lubetsky, and L. J. Stern (2001)
J. Biol. Chem. 276, 28068-28074
   Abstract »    Full Text »    PDF »
Inaugural Article: Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance.
R. M. Steinman and M. C. Nussenzweig (2002)
PNAS 99, 351-358
   Abstract »    Full Text »    PDF »


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