Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 21 April 2000:
Vol. 288. no. 5465, pp. 514 - 517
DOI: 10.1126/science.288.5465.514
|
|
Reports
Emergence of Genetic Instability in Children Treated for Leukemia
B. A. Finette,
123*
A. C. Homans,
13
R. J. Albertini
234
T cells from patients who had received
chemotherapy for B-lineage acute lymphocytic leukemia were studied to
determine whether genetic instability, a principal characteristic of
cancer cells, can also occur in nonmalignant cells. Consistent with
expectations for a genetic instability phenotype, multiple mutations
were detected in the hypoxanthine-guanine phosphoribosyltransferase
(HPRT) reporter gene in independently isolated
mutant T cells expressing identical rearranged T cell receptor  (TCR) gene hypervariable regions. These results indicate that cancer
treatment can lead to genetic instability in nonmalignant cells in some
individuals. They also suggest a mechanistic paradigm for the induction
of second malignancies and drug resistance.
1 Department of Pediatrics,
2 Department of
Microbiology and Molecular Genetics,
3 Vermont Cancer
Center, and
4 Department of Medicine, University of Vermont,
Medical Alumni Building, Burlington, VT 05405, USA.
*
To whom correspondence should be addressed. E-mail:
finette{at}salus.med.uvm.edu
Read the Full Text
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Analysis of Genetic Alterations and Clonal Proliferation in Children Treated for Acute Lymphocytic Leukemia..
- H. E. Kendall, P. M. Vacek, J. L. Rivers, S. C. Rice, T. L. Messier, and B. A. Finette (2006)
Cancer Res.
66, 8455-8461
| Abstract »
| Full Text »
| PDF »
- Clusters of mutations from transient hypermutability.
- J. W. Drake, A. Bebenek, G. E. Kissling, and S. Peddada (2005)
PNAS
102, 12849-12854
| Abstract »
| Full Text »
| PDF »
- Analysis of microsatellite instability in children treated for acute lymphocytic leukemia with elevated HPRT mutant frequencies.
- H. E. Kendall, P. M. Vacek, and B. A. Finette (2004)
Mutagenesis
19, 409-412
| Abstract »
| Full Text »
| PDF »
- Genotoxicity of Therapeutic Intervention in Children with Acute Lymphocytic Leukemia.
- S. C. Rice, P. Vacek, A. H. Homans, T. Messier, J. Rivers, H. Kendall, and B. A. Finette (2004)
Cancer Res.
64, 4464-4471
| Abstract »
| Full Text »
| PDF »
- The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage.
- L. M. Colgin, A. F. M. Hackmann, M. J. Emond, and R. J. Monnat Jr. (2002)
PNAS
| Abstract »
| Full Text »
| PDF »
- Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria.
- K. Horikawa, T. Kawaguchi, S. Ishihara, S. Nagakura, M. Hidaka, T. Kagimoto, H. Mitsuya, and H. Nakakuma (2002)
Blood
99, 24-29
| Abstract »
| Full Text »
| PDF »
- The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage.
- L. M. Colgin, A. F. M. Hackmann, M. J. Emond, and R. J. Monnat Jr. (2002)
PNAS
99, 1437-1442
| Abstract »
| Full Text »
| PDF »
|
|
