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Science 24 March 2000:
Vol. 287. no. 5461, pp. 2262 - 2267
DOI: 10.1126/science.287.5461.2262
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Reports

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

Yasunori Hayashi, * Song-Hai Shi, * José A. Esteban, Antonella Piccini, Jean-Christophe Poncer, dagger Roberto Malinow ddagger

To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha -amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag were expressed in rat hippocampal neurons. Long-term potentiation (LTP) or increased activity of the calcium/calmodulin-dependent protein kinase II (CaMKII) induced delivery of tagged AMPA-Rs into synapses. This effect was not diminished by mutating the CaMKII phosphorylation site on the GluR1 AMPA-R subunit, but was blocked by mutating a predicted PDZ domain interaction site. These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
*   These authors contributed equally to this work.

dagger    Present address: INSERM U261, Institut Pasteur, 25 rue du Dr. Roux, 75015 Paris, France.

ddagger    To whom correspondence should be addressed. E-mail: malinow{at}cshl.org

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From the Cover: Imaging of receptor trafficking by using {alpha}-bungarotoxin-binding-site-tagged receptors.
Y. Sekine-Aizawa and R. L. Huganir (2004)
PNAS 101, 17114-17119
   Abstract »    Full Text »    PDF »
Persistent Accumulation of Calcium/Calmodulin-Dependent Protein Kinase II in Dendritic Spines after Induction of NMDA Receptor-Dependent Chemical Long-Term Potentiation.
N. Otmakhov, J.-H. Tao-Cheng, S. Carpenter, B. Asrican, A. Dosemeci, T. S. Reese, and J. Lisman (2004)
J. Neurosci. 24, 9324-9331
   Abstract »    Full Text »    PDF »
Local Control of AMPA Receptor Trafficking at the Postsynaptic Terminal by a Small GTPase of the Rab Family.
N. Z. Gerges, D. S. Backos, and J. A. Esteban (2004)
J. Biol. Chem. 279, 43870-43878
   Abstract »    Full Text »    PDF »
The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C-{alpha} and GluR2 as Interacting Ligands.
K. K. Dev, S. Nakanishi, and J. M. Henley (2004)
J. Biol. Chem. 279, 41393-41397
   Abstract »    Full Text »    PDF »
Actin/{alpha}-Actinin-Dependent Transport of AMPA Receptors in Dendritic Spines: Role of the PDZ-LIM Protein RIL.
T. W. Schulz, T. Nakagawa, P. Licznerski, V. Pawlak, A. Kolleker, A. Rozov, J. Kim, T. Dittgen, G. Kohr, M. Sheng, et al. (2004)
J. Neurosci. 24, 8584-8594
   Abstract »    Full Text »    PDF »
From The Cover: The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation.
S.-H. Shi, T. Cheng, L. Y. Jan, and Y.-N. Jan (2004)
PNAS 101, 13346-13351
   Abstract »    Full Text »    PDF »
Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurones.
B. K. Andrasfalvy and J. C. Magee (2004)
J. Physiol. 559, 543-554
   Abstract »    Full Text »    PDF »
AMPA Receptor Synaptic Targeting Regulated by Stargazin Interactions with the Golgi-Resident PDZ Protein nPIST.
A. E. Cuadra, S.-H. Kuo, Y. Kawasaki, D. S. Bredt, and D. M. Chetkovich (2004)
J. Neurosci. 24, 7491-7502
   Abstract »    Full Text »    PDF »
Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors.
G.-Y. Xu and L.-Y. M. Huang (2004)
PNAS 101, 11868-11873
   Abstract »    Full Text »    PDF »
Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression.
J. Du, N. A. Gray, C. A. Falke, W. Chen, P. Yuan, S. T. Szabo, H. Einat, and H. K. Manji (2004)
J. Neurosci. 24, 6578-6589
   Abstract »    Full Text »    PDF »


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