Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 March 2000:
Vol. 287. no. 5460, pp. 2032 - 2036
DOI: 10.1126/science.287.5460.2032
Prev | Table of Contents | Next

Reports

Retinal Stem Cells in the Adult Mammalian Eye

Vincent Tropepe, 1 Brenda L. K. Coles, 1 Bernard J. Chiasson, 1 D. Jonathan Horsford, 24 Andrew J. Elia, 5 Roderick R. McInnes, 234 Derek van der Kooy 1*

The mature mammalian retina is thought to lack regenerative capacity. Here, we report the identification of a stem cell in the adult mouse eye, which represents a possible substrate for retinal regeneration. Single pigmented ciliary margin cells clonally proliferate in vitro to form sphere colonies of cells that can differentiate into retinal-specific cell types, including rod photoreceptors, bipolar neurons, and Müller glia. Adult retinal stem cells are localized to the pigmented ciliary margin and not to the central and peripheral retinal pigmented epithelium, indicating that these cells may be homologous to those found in the eye germinal zone of other nonmammalian vertebrates.

1 Department of Anatomy and Cell Biology, University of Toronto, Medical Sciences Building 1105, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
2 Programs in Developmental Biology and Genetics, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
3 Department of Pediatrics and
4 Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
5 Amgen Institute, Ontario Cancer Institute, and Departments of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada.
*   To whom correspondence should be addressed. E-mail: derek.van.der.kooy{at}utoronto.ca

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
cAMP Response Element Binding Protein Is Required for Mouse Neural Progenitor Cell Survival and Expansion.
S. Dworkin, J. Malaterre, F. Hollande, P. K. Darcy, R. G. Ramsay, and T. Mantamadiotis (2009)
Stem Cells 27, 1347-1357
   Abstract »    Full Text »    PDF »
Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone.
F. Kubo and S. Nakagawa (2009)
Development 136, 1823-1833
   Abstract »    Full Text »    PDF »
Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells.
S. A. Cicero, D. Johnson, S. Reyntjens, S. Frase, S. Connell, L. M. L. Chow, S. J. Baker, B. P. Sorrentino, and M. A. Dyer (2009)
PNAS 106, 6685-6690
   Abstract »    Full Text »    PDF »
Stem Cells as Tools in Regenerative Therapy for Retinal Degeneration.
V. Enzmann, E. Yolcu, H. J. Kaplan, and S. T. Ildstad (2009)
Arch Ophthalmol 127, 563-571
   Abstract »    Full Text »    PDF »
Somatic Stem Cells in the Endometrium.
I. Cervello and C. Simon (2009)
Reproductive Sciences 16, 200-205
   Abstract »    PDF »
Healing of Retinal Photocoagulation Lesions.
Y. M. Paulus, A. Jain, R. F. Gariano, B. V. Stanzel, M. Marmor, M. S. Blumenkranz, and D. Palanker (2008)
Invest. Ophthalmol. Vis. Sci. 49, 5540-5545
   Abstract »    Full Text »    PDF »
CD138/Syndecan-1 and SSEA-1 Mark Distinct Populations of Developing Ciliary Epithelium That Are Regulated Differentially by Wnt Signal.
H. Koso, A. Iida, Y. Tabata, Y. Baba, S. Satoh, M. M. Taketo, and S. Watanabe (2008)
Stem Cells 26, 3162-3171
   Abstract »    Full Text »    PDF »
Toll-like receptor 4 restricts retinal progenitor cell proliferation.
R. Shechter, A. Ronen, A. Rolls, A. London, S. Bakalash, M. J. Young, and M. Schwartz (2008)
J. Cell Biol. 183, 393-400
   Abstract »    Full Text »    PDF »
Don't Look: Growing Clonal Versus Nonclonal Neural Stem Cell Colonies.
B. L.K. Coles-Takabe, I. Brain, K. A. Purpura, P. Karpowicz, P. W. Zandstra, C. M. Morshead, and D. van der Kooy (2008)
Stem Cells 26, 2938-2944
   Abstract »    Full Text »    PDF »
Engrafted Chicken Neural Tube-Derived Stem Cells Support the Innate Propensity for Axonal Regeneration within the Rat Optic Nerve.
P. Charalambous, L. A. Hurst, and S. Thanos (2008)
Invest. Ophthalmol. Vis. Sci. 49, 3513-3524
   Abstract »    Full Text »    PDF »
Canonical Wnt Signaling Controls Proliferation of Retinal Stem/Progenitor Cells in Postembryonic Xenopus Eyes.
T. Denayer, M. Locker, C. Borday, T. Deroo, S. Janssens, A. Hecht, F. van Roy, M. Perron, and K. Vleminckx (2008)
Stem Cells 26, 2063-2074
   Abstract »    Full Text »    PDF »
Derivation of Neurons with Functional Properties from Adult Limbal Epithelium: Implications in Autologous Cell Therapy for Photoreceptor Degeneration.
X. Zhao, A. V. Das, S. Bhattacharya, W. B. Thoreson, J. R. Sierra, K. B. Mallya, and I. Ahmad (2008)
Stem Cells 26, 939-949
   Abstract »    Full Text »    PDF »
{alpha}-Aminoadipate Induces Progenitor Cell Properties of Muller Glia in Adult Mice.
M. Takeda, A. Takamiya, J.-w. Jiao, K.-S. Cho, S. G. Trevino, T. Matsuda, and D. F. Chen (2008)
Invest. Ophthalmol. Vis. Sci. 49, 1142-1150
   Abstract »    Full Text »    PDF »
Identification of Photoreceptor Precursors in the Pars Plana during Ocular Development and after Retinal Injury.
K. M. Nishiguchi, H. Kaneko, M. Nakamura, S. Kachi, and H. Terasaki (2008)
Invest. Ophthalmol. Vis. Sci. 49, 422-428
   Abstract »    Full Text »    PDF »
Induction of Functional Photoreceptor Phenotype by Exogenous Crx Expression in Mouse Retinal Stem Cells.
C. Jomary and S. E. Jones (2008)
Invest. Ophthalmol. Vis. Sci. 49, 429-437
   Abstract »    Full Text »    PDF »
Proliferation and Expression of Progenitor and Mature Retinal Phenotypes in the Adult Mammalian Ciliary Body after Retinal Ganglion Cell Injury.
P. E. B. Nickerson, J. G. Emsley, T. Myers, and D. B. Clarke (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5266-5275
   Abstract »    Full Text »    PDF »
Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells.
C. F. Kim (2007)
Am J Physiol Lung Cell Mol Physiol 293, L1092-L1098
   Abstract »    Full Text »    PDF »
Unique Glycerophospholipid Signature in Retinal Stem Cells Correlates with Enzymatic Functions of Diverse Long-Chain Acyl-CoA Synthetases.
J. Li, Z. Cui, S. Zhao, and R. L. Sidman (2007)
Stem Cells 25, 2864-2873
   Abstract »    Full Text »    PDF »
Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors.
M. Allocca, C. Mussolino, M. Garcia-Hoyos, D. Sanges, C. Iodice, M. Petrillo, L. H. Vandenberghe, J. M. Wilson, V. Marigo, E. M. Surace, et al. (2007)
J. Virol. 81, 11372-11380
   Abstract »    Full Text »    PDF »
Comparative Analysis of Progenitor Cells Isolated from the Iris, Pars Plana, and Ciliary Body of the Adult Porcine Eye.
A. MacNeil, R. A. Pearson, R. E. MacLaren, A. J. Smith, J. C. Sowden, and R. R. Ali (2007)
Stem Cells 25, 2430-2438
   Abstract »    Full Text »    PDF »
The effect of postmortem time, donor age and sex on the generation of neurospheres from adult human retina.
D. A Carter, E. J Mayer, and A. D Dick (2007)
Br. J. Ophthalmol. 91, 1216-1218
   Abstract »    Full Text »    PDF »
Adhesion Is Prerequisite, But Alone Insufficient, to Elicit Stem Cell Pluripotency.
P. Karpowicz, T. Inoue, S. Runciman, B. Deveale, R. Seaberg, M. Gertsenstein, L. Byers, Y. Yamanaka, S. Tondat, J. Slevin, et al. (2007)
J. Neurosci. 27, 5437-5447
   Abstract »    Full Text »    PDF »
Bone Marrow (BM) Transplantation Promotes {beta}-Cell Regeneration after Acute Injury through BM Cell Mobilization.
Y. Hasegawa, T. Ogihara, T. Yamada, Y. Ishigaki, J. Imai, K. Uno, J. Gao, K. Kaneko, H. Ishihara, H. Sasano, et al. (2007)
Endocrinology 148, 2006-2015
   Abstract »    Full Text »    PDF »
Wnt Signaling Promotes Regeneration in the Retina of Adult Mammals.
F. Osakada, S. Ooto, T. Akagi, M. Mandai, A. Akaike, and M. Takahashi (2007)
J. Neurosci. 27, 4210-4219
   Abstract »    Full Text »    PDF »
Characteristics of Progenitor Cells Derived from Adult Ciliary Body in Mouse, Rat, and Human Eyes.
H. Xu, D. D. Sta. Iglesia, J. L. Kielczewski, D. F. Valenta, M. E. Pease, D. J. Zack, and H. A. Quigley (2007)
Invest. Ophthalmol. Vis. Sci. 48, 1674-1682
   Abstract »    Full Text »    PDF »
Differences in Cyclin D2 and D1 Protein Expression Distinguish Forebrain Progenitor Subsets.
S. B. Glickstein, S. Alexander, and M. E. Ross (2007)
Cereb Cortex 17, 632-642
   Abstract »    Full Text »    PDF »
Molecular regulation of visual system development: more than meets the eye.
T. Harada, C. Harada, and L. F. Parada (2007)
Genes & Dev. 21, 367-378
   Abstract »    Full Text »    PDF »
Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis.
M. Geraerts, O. Krylyshkina, Z. Debyser, and V. Baekelandt (2007)
Stem Cells 25, 263-270
   Abstract »    Full Text »    PDF »
Subretinal Posterior Pole Injury Induces Selective Proliferation of RPE Cells in the Periphery in In Vivo Studies in Pigs.
J. F. Kiilgaard, J. U. Prause, M. Prause, E. Scherfig, M. H. Nissen, and M. la Cour (2007)
Invest. Ophthalmol. Vis. Sci. 48, 355-360
   Abstract »    Full Text »    PDF »
Identification, characterization and co-localization of label-retaining cell population in mouse endometrium with typical undifferentiated markers.
I. Cervello, J.A. Martinez-Conejero, J.A. Horcajadas, A. Pellicer, and C. Simon (2007)
Hum. Reprod. 22, 45-51
   Abstract »    Full Text »    PDF »
Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property.
A. P. Jadhav, S.-H. Cho, and C. L. Cepko (2006)
PNAS 103, 18998-19003
   Abstract »    Full Text »    PDF »
Isolation and Characterization of a Stem Cell Population from Adult Human Liver.
M. B. Herrera, S. Bruno, S. Buttiglieri, C. Tetta, S. Gatti, M. C. Deregibus, B. Bussolati, and G. Camussi (2006)
Stem Cells 24, 2840-2850
   Abstract »    Full Text »    PDF »
Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors.
D. Sanges, A. Comitato, R. Tammaro, and V. Marigo (2006)
PNAS 103, 17366-17371
   Abstract »    Full Text »    PDF »
A Comparison of Neural Differentiation and Retinal Transplantation with Bone Marrow-Derived Cells and Retinal Progenitor Cells.
M. Tomita, T. Mori, K. Maruyama, T. Zahir, M. Ward, A. Umezawa, and M. J. Young (2006)
Stem Cells 24, 2270-2278
   Abstract »    Full Text »    PDF »
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells.
U Shivraj Sohur, J. G Emsley, B. D Mitchell, and J. D Macklis (2006)
Phil Trans R Soc B 361, 1477-1497
   Abstract »    Full Text »    PDF »
High Yield of Cells Committed to the Photoreceptor Fate from Expanded Mouse Retinal Stem Cells.
F. Merhi-Soussi, B. Angenieux, K. Canola, C. Kostic, M. Tekaya, D. Hornfeld, and Y. Arsenijevic (2006)
Stem Cells 24, 2060-2070
   Abstract »    Full Text »    PDF »
Wnt2b/{beta}-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye.
S.-H. Cho and C. L. Cepko (2006)
Development 133, 3167-3177
   Abstract »    Full Text »    PDF »
Form deprivation modulates retinal neurogenesis in primate experimental myopia.
A. V. Tkatchenko, P. A. Walsh, T. V. Tkatchenko, S. Gustincich, and E. Raviola (2006)
PNAS 103, 4681-4686
   Abstract »    Full Text »    PDF »
Absence of Chx10 Causes Neural Progenitors to Persist in the Adult Retina.
N. S. Dhomen, K. S. Balaggan, R. A. Pearson, J. W. Bainbridge, E. M. Levine, R. R. Ali, and J. C. Sowden (2006)
Invest. Ophthalmol. Vis. Sci. 47, 386-396
   Abstract »    Full Text »    PDF »
Activation of Canonical Wnt Pathway Promotes Proliferation of Retinal Stem Cells Derived from Adult Mouse Ciliary Margin.
T. Inoue, T. Kagawa, M. Fukushima, T. Shimizu, Y. Yoshinaga, S. Takada, H. Tanihara, and T. Taga (2006)
Stem Cells 24, 95-104
   Abstract »    Full Text »    PDF »
Glucagon-Expressing Neurons within the Retina Regulate the Proliferation of Neural Progenitors in the Circumferential Marginal Zone of the Avian Eye.
A. J. Fischer, G. Omar, N. A. Walton, T. A. Verrill, and C. G. Unson (2005)
J. Neurosci. 25, 10157-10166
   Abstract »    Full Text »    PDF »
Comparison of Rabbit Corneal Endothelial Cell Precursors in the Central and Peripheral Cornea.
T. Mimura, S. Yamagami, S. Yokoo, M. Araie, and S. Amano (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3645-3648
   Abstract »    Full Text »    PDF »
Biodegradable Polymer Composite Grafts Promote the Survival and Differentiation of Retinal Progenitor Cells.
M. Tomita, E. Lavik, H. Klassen, T. Zahir, R. Langer, and M. J. Young (2005)
Stem Cells 23, 1579-1588
   Abstract »    Full Text »    PDF »
Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart.
Y. Tomita, K. Matsumura, Y. Wakamatsu, Y. Matsuzaki, I. Shibuya, H. Kawaguchi, M. Ieda, S. Kanakubo, T. Shimazaki, S. Ogawa, et al. (2005)
J. Cell Biol. 170, 1135-1146
   Abstract »    Full Text »    PDF »
Sphere Therapy for Corneal Endothelium Deficiency in a Rabbit Model.
T. Mimura, S. Yamagami, S. Yokoo, Y. Yanagi, T. Usui, K. Ono, M. Araie, and S. Amano (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3128-3135
   Abstract »    Full Text »    PDF »
Iris-Derived Cells from Adult Rodents and Primates Adopt Photoreceptor-Specific Phenotypes.
T. Akagi, J. Akita, M. Haruta, T. Suzuki, Y. Honda, T. Inoue, S. Yoshiura, R. Kageyama, T. Yatsu, M. Yamada, et al. (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3411-3419
   Abstract »    Full Text »    PDF »
The Adult Pituitary Contains a Cell Population Displaying Stem/Progenitor Cell and Early Embryonic Characteristics.
J. Chen, N. Hersmus, V. V. Duppen, P. Caesens, C. Denef, and H. Vankelecom (2005)
Endocrinology 146, 3985-3998
   Abstract »    Full Text »    PDF »
Isolation and Characterization of Neurogenic Mesenchymal Stem Cells in Human Scalp Tissue.
D. T.-b. Shih, D.-C. Lee, S.-C. Chen, R.-Y. Tsai, C.-T. Huang, C.-C. Tsai, E.-Y. Shen, and W.-T. Chiu (2005)
Stem Cells 23, 1012-1020
   Abstract »    Full Text »    PDF »
Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF{beta} signaling.
J. L. Close, B. Gumuscu, and T. A. Reh (2005)
Development 132, 3015-3026
   Abstract »    Full Text »    PDF »
Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes.
F. Kubo, M. Takeichi, and S. Nakagawa (2005)
Development 132, 2759-2770
   Abstract »    Full Text »    PDF »
Sphere Formation and Expression of Neural Proteins by Human Corneal Stromal Cells In Vitro.
S. Uchida, S. Yokoo, Y. Yanagi, T. Usui, C. Yokota, T. Mimura, M. Araie, S. Yamagami, and S. Amano (2005)
Invest. Ophthalmol. Vis. Sci. 46, 1620-1625
   Abstract »    Full Text »    PDF »
Human Corneal Endothelial Cell Precursors Isolated by Sphere-Forming Assay.
S. Yokoo, S. Yamagami, Y. Yanagi, S. Uchida, T. Mimura, T. Usui, and S. Amano (2005)
Invest. Ophthalmol. Vis. Sci. 46, 1626-1631
   Abstract »    Full Text »    PDF »
Nestin-Immunoreactive Cells in Rat Pituitary Are neither Hormonal nor Typical Folliculo-Stellate Cells.
O. Krylyshkina, J. Chen, L. Mebis, C. Denef, and H. Vankelecom (2005)
Endocrinology 146, 2376-2387
   Abstract »    Full Text »    PDF »
Identification of Zebrafish Insertional Mutants With Defects in Visual System Development and Function.
J. M. Gross, B. D. Perkins, A. Amsterdam, A. Egana, T. Darland, J. I. Matsui, S. Sciascia, N. Hopkins, and J. E. Dowling (2005)
Genetics 170, 245-261
   Abstract »    Full Text »    PDF »
Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor.
N. Azuma, K. Tadokoro, A. Asaka, M. Yamada, Y. Yamaguchi, H. Handa, S. Matsushima, T. Watanabe, Y. Kida, T. Ogura, et al. (2005)
Hum. Mol. Genet. 14, 1059-1068
   Abstract »    Full Text »    PDF »
Isolation of Murine and Porcine Fetal Stem Cells from Somatic Tissue.
W. A. Kues, B. Petersen, W. Mysegades, J. W. Carnwath, and H. Niemann (2005)
Biol Reprod 72, 1020-1028
   Abstract »    Full Text »    PDF »
Effects of Ciliary Neurotrophic Factor on Differentiation of Late Retinal Progenitor Cells.
T. Zahir, H. Klassen, and M. J. Young (2005)
Stem Cells 23, 424-432
   Abstract »    Full Text »    PDF »
Characterization and Distribution of Bone Marrow-Derived Cells in Mouse Cornea.
T. Nakamura, F. Ishikawa, K.-h. Sonoda, T. Hisatomi, H. Qiao, J. Yamada, M. Fukata, T. Ishibashi, M. Harada, and S. Kinoshita (2005)
Invest. Ophthalmol. Vis. Sci. 46, 497-503
   Abstract »    Full Text »    PDF »
Isolation of Renal Progenitor Cells from Adult Human Kidney.
B. Bussolati, S. Bruno, C. Grange, S. Buttiglieri, M. C. Deregibus, D. Cantino, and G. Camussi (2005)
Am. J. Pathol. 166, 545-555
   Abstract »    Full Text »    PDF »
Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity.
D. J. Horsford, M.-T. T. Nguyen, G. C. Sellar, R. Kothary, H. Arnheiter, and R. R. McInnes (2005)
Development 132, 177-187
   Abstract »    Full Text »    PDF »
Neural progenitor cells from postmortem adult human retina.
E J Mayer, D A Carter, Y Ren, E H Hughes, C M Rice, C A Halfpenny, N J Scolding, and A D Dick (2005)
Br. J. Ophthalmol. 89, 102-106
   Abstract »    Full Text »    PDF »
Otx2 Homeobox Gene Induces Photoreceptor-Specific Phenotypes in Cells Derived from Adult Iris and Ciliary Tissue.
T. Akagi, M. Mandai, S. Ooto, Y. Hirami, F. Osakada, R. Kageyama, N. Yoshimura, and M. Takahashi (2004)
Invest. Ophthalmol. Vis. Sci. 45, 4570-4575
   Abstract »    Full Text »    PDF »
Facile isolation and the characterization of human retinal stem cells.
B. L. K. Coles, B. Angenieux, T. Inoue, K. Del Rio-Tsonis, J. R. Spence, R. R. McInnes, Y. Arsenijevic, and D. van der Kooy (2004)
PNAS 101, 15772-15777
   Abstract »    Full Text »    PDF »
Multipotent Retinal Progenitors Express Developmental Markers, Differentiate into Retinal Neurons, and Preserve Light-Mediated Behavior.
H. J. Klassen, T. F. Ng, Y. Kurimoto, I. Kirov, M. Shatos, P. Coffey, and M. J. Young (2004)
Invest. Ophthalmol. Vis. Sci. 45, 4167-4173
   Abstract »    Full Text »    PDF »
Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10.
S. Rowan, C.-M. A. Chen, T. L. Young, D. E. Fisher, and C. L. Cepko (2004)
Development 131, 5139-5152
   Abstract »    Full Text »    PDF »
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina.
S. Ooto, T. Akagi, R. Kageyama, J. Akita, M. Mandai, Y. Honda, and M. Takahashi (2004)
PNAS 101, 13654-13659
   Abstract »    Full Text »    PDF »
Prospective Isolation of Multipotent Pancreatic Progenitors Using Flow-Cytometric Cell Sorting.
A. Suzuki, H. Nakauchi, and H. Taniguchi (2004)
Diabetes 53, 2143-2152
   Abstract »    Full Text »    PDF »
Mouse models of childhood cancer of the nervous system.
M A Dyer (2004)
J. Clin. Pathol. 57, 561-576
   Abstract »    Full Text »    PDF »
Retinal progenitor cells in the posterior pars plana of rhesus monkeys.
J B Jonas, S Panda-Jonas, and S Singh Hayreh (2004)
Br. J. Ophthalmol. 88, 836-837
   Full Text »    PDF »
The Cognition-Enhancer Nefiracetam Inhibits Both Necrosis and Apoptosis in Retinal Ischemic Models in Vitro and in Vivo.
M. Ueda, R. Fujita, T. Koji, and H. Ueda (2004)
J. Pharmacol. Exp. Ther. 309, 200-207
   Abstract »    Full Text »
Stem Cell Therapy for Ocular Disorders.
L. A. Levin, R. Ritch, J. E. Richards, and T. Borras (2004)
Arch Ophthalmol 122, 621-627
   Abstract »    Full Text »    PDF »
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.
V. Palma and A. R. i Altaba (2004)
Development 131, 337-345
   Abstract »    Full Text »    PDF »
Persistent Progenitors at the Retinal Margin of ptc+/- Mice.
A. Moshiri and T. A. Reh (2004)
J. Neurosci. 24, 229-237
   Abstract »    Full Text »    PDF »
Enhanced Induction of RPE Lineage Markers in Pluripotent Neural Stem Cells Engrafted into the Adult Rat Subretinal Space.
V. Enzmann, R. M. Howard, Y. Yamauchi, S. R. Whittemore, and H. J. Kaplan (2003)
Invest. Ophthalmol. Vis. Sci. 44, 5417-5422
   Abstract »    Full Text »    PDF »
Distinct Populations of Forebrain Neural Stem and Progenitor Cells Can Be Isolated Using Side-Population Analysis.
M. Kim and C. M. Morshead (2003)
J. Neurosci. 23, 10703-10709
   Abstract »    Full Text »    PDF »
From The Cover: Generation of hair cells by stepwise differentiation of embryonic stem cells.
H. Li, G. Roblin, H. Liu, and S. Heller (2003)
PNAS 100, 13495-13500
   Abstract »    Full Text »    PDF »
Triple Immune Suppression Increases Short-Term Survival of Porcine Fetal Retinal Pigment Epithelium Xenografts.
L. V. Del Priore, O. Ishida, E. W. Johnson, Y. Sheng, D. B. Jacoby, L. Geng, T. H. Tezel, and H. J. Kaplan (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4044-4053
   Abstract »    Full Text »    PDF »
Therapy may yet stem from cells in the retina.
R R Ali and J C Sowden (2003)
Br. J. Ophthalmol. 87, 1058-1059
   Full Text »    PDF »
Nestin positive cells in adult human retina and in epiretinal membranes.
E J Mayer, E H Hughes, D A Carter, and A D Dick (2003)
Br. J. Ophthalmol. 87, 1154-1158
   Abstract »    Full Text »    PDF »
Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye.
A. Kicic, W.-Y. Shen, A. S. Wilson, I. J. Constable, T. Robertson, and P. E. Rakoczy (2003)
J. Neurosci. 23, 7742-7749
   Abstract »    Full Text »    PDF »
Retinal transplantation: progress and problems in clinical application.
R. D. Lund, S. J. Ono, D. J. Keegan, and J. M. Lawrence (2003)
J. Leukoc. Biol. 74, 151-160
   Abstract »    Full Text »    PDF »
Label-Retaining Cells in the Rat Pancreas: Location and Differentiation Potential in Vitro.
B. Duvillie, M. Attali, V. Aiello, E. Quemeneur, and R. Scharfmann (2003)
Diabetes 52, 2035-2042
   Abstract »    Full Text »    PDF »
Engraftment of Adult Neural Progenitor Cells Transplanted to Rat Retina Injured by Transient Ischemia.
Y. Guo, P. Saloupis, S. J. Shaw, and D. W. Rickman (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3194-3201
   Abstract »    Full Text »    PDF »
Age-Dependent Changes in the Basal Retinovitreous Adhesion.
J. Wang, D. McLeod, D. B. Henson, and P. N. Bishop (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1793-1800
   Abstract »    Full Text »    PDF »
Cell Cycle Regulation in Retinal Progenitors by Glia-Derived Neurotrophic Factor and Docosahexaenoic Acid.
M. F. Insua, A. Garelli, N. P. Rotstein, O. L. German, A. Arias, and L. E. Politi (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2235-2244
   Abstract »    Full Text »    PDF »
A novel function for Hedgehog signalling in retinal pigment epithelium differentiation.
M. Perron, S. Boy, M. A. Amato, A. Viczian, K. Koebernick, T. Pieler, and W. A. Harris (2003)
Development 130, 1565-1577
   Abstract »    Full Text »    PDF »
Invasion of Retinal Pigment Epithelial Cells: N-cadherin, Hepatocyte Growth Factor, and Focal Adhesion Kinase.
E. H. Van Aken, O. De Wever, L. Van Hoorde, E. Bruyneel, J.-J. De Laey, and M. M. Mareel (2003)
Invest. Ophthalmol. Vis. Sci. 44, 463-472
   Abstract »    Full Text »    PDF »
Non-neural Regions of the Adult Human Eye: A Potential Source of Neurons?.
Y. Arsenijevic, N. Taverney, C. Kostic, M. Tekaya, F. Riva, L. Zografos, D. Schorderet, and F. Munier (2003)
Invest. Ophthalmol. Vis. Sci. 44, 799-807
   Abstract »    Full Text »    PDF »
Wnt2b controls retinal cell differentiation at the ciliary marginal zone.
F. Kubo, M. Takeichi, and S. Nakagawa (2003)
Development 130, 587-598
   Abstract »    Full Text »    PDF »
Age-Related Changes in Human RPE Cell Density and Apoptosis Proportion In Situ.
L. V. Del Priore, Y.-H. Kuo, and T. H. Tezel (2002)
Invest. Ophthalmol. Vis. Sci. 43, 3312-3318
   Abstract »    Full Text »    PDF »
Terminal Bronchioles Harbor a Unique Airway Stem Cell Population That Localizes to the Bronchoalveolar Duct Junction.
A. Giangreco, S. D. Reynolds, and B. R. Stripp (2002)
Am. J. Pathol. 161, 173-182
   Abstract »    Full Text »    PDF »
Site-Specific Somatic Mutagenesis in the Retinal Pigment Epithelium.
M. Mori, D. Metzger, J.-M. Garnier, P. Chambon, and M. Mark (2002)
Invest. Ophthalmol. Vis. Sci. 43, 1384-1388
   Abstract »    Full Text »    PDF »
Adult Rodent Neurogenic Regions: The Ventricular Subependyma Contains Neural Stem Cells, But the Dentate Gyrus Contains Restricted Progenitors.
R. M. Seaberg and D. van der Kooy (2002)
J. Neurosci. 22, 1784-1793
   Abstract »    Full Text »    PDF »
Long-Term Survival and Glial Differentiation of the Brain-Derived Precursor Cell Line RN33B after Subretinal Transplantation to Adult Normal Rats.
A. B. Wojciechowski, U. Englund, C. Lundberg, and K. Warfvinge (2002)
Stem Cells 20, 163-173
   Abstract »    Full Text »    PDF »
Exogenous growth factors induce the production of ganglion cells at the retinal margin.
A. J. Fischer, B. D. Dierks, and T. A. Reh (2002)
Development 129, 2283-2291
   Abstract »    Full Text »    PDF »
Postembryonic development of the posterior lateral line in zebrafish.
V. Ledent (2002)
Development 129, 597-604
   Abstract »    Full Text »    PDF »
Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.
S. Hitoshi, V. Tropepe, M. Ekker, and D. van der Kooy (2002)
Development 129, 233-244
   Abstract »    Full Text »    PDF »
The Fate of Heterotopically Grafted Neural Precursor Cells in the Normal and Dystrophic Adult Mouse Retina.
S. Pressmar, M. Ader, G. Richard, M. Schachner, and U. Bartsch (2001)
Invest. Ophthalmol. Vis. Sci. 42, 3311-3319
   Abstract »    Full Text »    PDF »
Stem Cells: New Opportunities to Treat Eye Diseases.
I. Ahmad (2001)
Invest. Ophthalmol. Vis. Sci. 42, 2743-2748
   Full Text »    PDF »
Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium.
G. Bernier, W. Vukovich, L. Neidhardt, B. G. Herrmann, and P. Gruss (2001)
Development 128, 3987-3994
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)