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Science 17 March 2000:
Vol. 287. no. 5460, pp. 2032 - 2036
DOI: 10.1126/science.287.5460.2032
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Reports

Retinal Stem Cells in the Adult Mammalian Eye

Vincent Tropepe, 1 Brenda L. K. Coles, 1 Bernard J. Chiasson, 1 D. Jonathan Horsford, 24 Andrew J. Elia, 5 Roderick R. McInnes, 234 Derek van der Kooy 1*

The mature mammalian retina is thought to lack regenerative capacity. Here, we report the identification of a stem cell in the adult mouse eye, which represents a possible substrate for retinal regeneration. Single pigmented ciliary margin cells clonally proliferate in vitro to form sphere colonies of cells that can differentiate into retinal-specific cell types, including rod photoreceptors, bipolar neurons, and Müller glia. Adult retinal stem cells are localized to the pigmented ciliary margin and not to the central and peripheral retinal pigmented epithelium, indicating that these cells may be homologous to those found in the eye germinal zone of other nonmammalian vertebrates.

1 Department of Anatomy and Cell Biology, University of Toronto, Medical Sciences Building 1105, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
2 Programs in Developmental Biology and Genetics, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
3 Department of Pediatrics and
4 Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
5 Amgen Institute, Ontario Cancer Institute, and Departments of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada.
*   To whom correspondence should be addressed. E-mail: derek.van.der.kooy{at}utoronto.ca

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Science. ISSN 0036-8075 (print), 1095-9203 (online)