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Science 10 March 2000:
Vol. 287. no. 5459, pp. 1820 - 1824
DOI: 10.1126/science.287.5459.1820
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Reports

gridlock, an HLH Gene Required for Assembly of the Aorta in Zebrafish

Tao P. Zhong, * Michael Rosenberg, *dagger Manzoor-Ali P. K. Mohideen, ddagger Brant Weinstein, § Mark C. Fishman parallel

The first artery and vein of the vertebrate embryo assemble in the trunk by migration and coalescence of angioblasts to form endothelial tubes. The gridlock (grl) mutation in zebrafish selectively perturbs assembly of the artery (the aorta). Here it is shown that grl encodes a basic helix-loop-helix (bHLH) protein belonging to the Hairy/Enhancer of the split family of bHLH proteins. The grl gene is expressed in lateral plate mesoderm before vessel formation, and thereafter in the aorta and not in the vein. These results suggest that the arterial endothelial identity is established even before the onset of blood flow and implicate the grl gene in assignment of vessel-specific cell fate.

Cardiovascular Research Center, Massachusetts General Hospital-Harvard Medical School, 149 13th Street, 4th floor, Charlestown, MA 02129, USA.
*   These authors contributed equally to this work.

dagger    Present address: Aventis Pharma, 26 Landsdowne Street, Cambridge, MA 02139, USA.

ddagger    Present address: Jake Gittlen Cancer Research Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

§   Present address: Unit on Vertebrate Organogenesis, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA.

parallel    To whom correspondence should be addressed. E-mail: fishman{at}cvrc.mgh.harvard.edu

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