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Science 10 March 2000:
Vol. 287. no. 5459, pp. 1809 - 1815
DOI: 10.1126/science.287.5459.1809
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Reports

Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58

Hervé Tettelin, 1* Nigel J. Saunders, 2 John Heidelberg, 1 Alex C. Jeffries, 2 Karen E. Nelson, 1 Jonathan A. Eisen, 1 Karen A. Ketchum, 1dagger Derek W. Hood, 2 John F. Peden, 2 Robert J. Dodson, 1 William C. Nelson, 1 Michelle L. Gwinn, 1 Robert DeBoy, 1 Jeremy D. Peterson, 1 Erin K. Hickey, 1 Daniel H. Haft, 1 Steven L. Salzberg, 1 Owen White, 1 Robert D. Fleischmann, 1 Brian A. Dougherty, 1 Tanya Mason, 1 Anne Ciecko, 1 Debbie S. Parksey, 1 Eric Blair, 1 Henry Cittone, 1 Emily B. Clark, 1 Matthew D. Cotton, 1 Terry R. Utterback, 1 Hoda Khouri, 1 Haiying Qin, 1 Jessica Vamathevan, 1 John Gill, 1 Vincenzo Scarlato, 3 Vega Masignani, 3 Mariagrazia Pizza, 3 Guido Grandi, 3 Li Sun, 2 Hamilton O. Smith, 1dagger Claire M. Fraser, 1 E. Richard Moxon, 2 Rino Rappuoli, 3 J. Craig Venter 1dagger

The 2,272,351-base pair genome of Neisseria meningitidis strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. Three major islands of horizontal DNA transfer were identified; two of these contain genes encoding proteins involved in pathogenicity, and the third island contains coding sequences only for hypothetical proteins. Insights into the commensal and virulence behavior of N. meningitidis can be gleaned from the genome, in which sequences for structural proteins of the pilus are clustered and several coding regions unique to serogroup B capsular polysaccharide synthesis can be identified. Finally, N. meningitidis contains more genes that undergo phase variation than any pathogen studied to date, a mechanism that controls their expression and contributes to the evasion of the host immune system.

1 The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.
2 Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK.
3 Immunological Research Institute of Siena (IRIS), Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy.
*   To whom correspondence should be addressed. E-mail: tettelin{at}tigr.org

dagger    Present address: Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.

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   Abstract »    Full Text »    PDF »
{delta}{rho}-Web, an online tool to assess composition similarity of individual nucleic acid sequences.
M. W. J. van Passel, A. C. M. Luyf, A. H. C. van Kampen, A. Bart, and A. van der Ende (2005)
Bioinformatics 21, 3053-3055
   Abstract »    Full Text »    PDF »
Nitric Oxide Detoxification Systems Enhance Survival of Neisseria meningitidis in Human Macrophages and in Nasopharyngeal Mucosa.
T. M. Stevanin, J. W. B. Moir, and R. C. Read (2005)
Infect. Immun. 73, 3322-3329
   Abstract »    Full Text »    PDF »
Identification, Distribution, and Expression of Novel Genes in 10 Clinical Isolates of Nontypeable Haemophilus influenzae.
K. Shen, P. Antalis, J. Gladitz, S. Sayeed, A. Ahmed, S. Yu, J. Hayes, S. Johnson, B. Dice, R. Dopico, et al. (2005)
Infect. Immun. 73, 3479-3491
   Abstract »    Full Text »    PDF »
Available carbon source influences the resistance of Neisseria meningitidis against complement.
R. M. Exley, J. Shaw, E. Mowe, Y.-h. Sun, N. P. West, M. Williamson, M. Botto, H. Smith, and C. M. Tang (2005)
J. Exp. Med. 201, 1637-1645
   Abstract »    Full Text »    PDF »
CrgA Is an Inducible LysR-Type Regulator of Neisseria meningitidis, Acting both as a Repressor and as an Activator of Gene Transcription.
R. Ieva, C. Alaimo, I. Delany, G. Spohn, R. Rappuoli, and V. Scarlato (2005)
J. Bacteriol. 187, 3421-3430
   Abstract »    Full Text »    PDF »
Future Directions In Vaccines: The Payoffs Of Basic Research.
S. Landry and C. Heilman (2005)
Health Aff. 24, 758-769
   Abstract »    Full Text »    PDF »
Antimutator Role of DNA Glycosylase MutY in Pathogenic Neisseria Species.
T. Davidsen, M. Bjoras, E. C. Seeberg, and T. Tonjum (2005)
J. Bacteriol. 187, 2801-2809
   Abstract »    Full Text »    PDF »
Function of Neisserial Outer Membrane Phospholipase A in Autolysis and Assessment of Its Vaccine Potential.
M. P. Bos, B. Tefsen, P. Voet, V. Weynants, J. P. M. van Putten, and J. Tommassen (2005)
Infect. Immun. 73, 2222-2231
   Abstract »    Full Text »    PDF »
Vaccines against bacterial meningitis.
S. Segal and A. J. Pollard (2005)
Br. Med. Bull. 72, 65-81
   Abstract »    Full Text »    PDF »
Translocation and Surface Expression of Lipidated Serogroup B Capsular Polysaccharide in Neisseria meningitidis.
Y.-L. Tzeng, A. K. Datta, C. A. Strole, M. A. Lobritz, R. W. Carlson, and D. S. Stephens (2005)
Infect. Immun. 73, 1491-1505
   Abstract »    Full Text »    PDF »
Analysis of the Piv Recombinase-Related Gene Family of Neisseria gonorrhoeae.
E. P. Skaar, B. LeCuyer, A. G. Lenich, M. P. Lazio, D. Perkins-Balding, H. S. Seifert, and A. C. Karls (2005)
J. Bacteriol. 187, 1276-1286
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A Single Bifunctional UDP-GlcNAc/Glc 4-Epimerase Supports the Synthesis of Three Cell Surface Glycoconjugates in Campylobacter jejuni.
S. Bernatchez, C. M. Szymanski, N. Ishiyama, J. Li, H. C. Jarrell, P. C. Lau, A. M. Berghuis, N. M. Young, and W. W. Wakarchuk (2005)
J. Biol. Chem. 280, 4792-4802
   Abstract »    Full Text »    PDF »
The Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC.
K. Prochazkova, R. Osicka, I. Linhartova, P. Halada, M. Sulc, and P. Sebo (2005)
J. Biol. Chem. 280, 3251-3258
   Abstract »    Full Text »    PDF »
The Region Comprising Amino Acids 100 to 255 of Neisseria meningitidis Lipoprotein GNA 1870 Elicits Bactericidal Antibodies.
M. M. Giuliani, L. Santini, B. Brunelli, A. Biolchi, B. Arico, F. Di Marcello, E. Cartocci, M. Comanducci, V. Masignani, L. Lozzi, et al. (2005)
Infect. Immun. 73, 1151-1160
   Abstract »    Full Text »    PDF »
Profiling the humoral immune response to infection by using proteome microarrays: High-throughput vaccine and diagnostic antigen discovery.
D. H. Davies, X. Liang, J. E. Hernandez, A. Randall, S. Hirst, Y. Mu, K. M. Romero, T. T. Nguyen, M. Kalantari-Dehaghi, S. Crotty, et al. (2005)
PNAS 102, 547-552
   Abstract »    Full Text »    PDF »
Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins.
K. A. Brayton, L. S. Kappmeyer, D. R. Herndon, M. J. Dark, D. L. Tibbals, G. H. Palmer, T. C. McGuire, and D. P. Knowles Jr. (2005)
PNAS 102, 844-849
   Abstract »    Full Text »    PDF »
Proteomics Analysis by Two-Dimensional Differential Gel Electrophoresis Reveals the Lack of a Broad Response of Neisseria meningitidis to In Vitro-Produced AI-2.
S. Schauder, L. Penna, A. Ritton, C. Manin, F. Parker, and G. Renauld-Mongenie (2005)
J. Bacteriol. 187, 392-395
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Genome Comparison In Silico in Neisseria Suggests Integration of Filamentous Bacteriophages by their Own Transposase.
M. Kawai, I. Uchiyama, and I. Kobayashi (2005)
DNA Res 12, 389-401
   Abstract »    Full Text »    PDF »
Identification of genes with fast-evolving regions in microbial genomes.
Y. Zheng, R. J. Roberts, and S. Kasif (2004)
Nucleic Acids Res. 32, 6347-6357
   Abstract »    Full Text »    PDF »
Identification of Neisseria meningitidis Genetic Loci Involved in the Modulation of Phase Variation Frequencies.
H. L. Alexander, A. W. Rasmussen, and I. Stojiljkovic (2004)
Infect. Immun. 72, 6743-6747
   Abstract »    Full Text »    PDF »
lpt6, a Gene Required for Addition of Phosphoethanolamine to Inner-Core Lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae.
J. C. Wright, D. W. Hood, G. A. Randle, K. Makepeace, A. D. Cox, J. Li, R. Chalmers, J. C. Richards, and E. R. Moxon (2004)
J. Bacteriol. 186, 6970-6982
   Abstract »    Full Text »    PDF »


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