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Science 3 March 2000:
Vol. 287. no. 5458, pp. 1664 - 1666
DOI: 10.1126/science.287.5458.1664
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Reports

Epitopes Involved in Antibody-Mediated Protection from Ebola Virus

Julie A. Wilson, Michael Hevey, Russell Bakken, Shawn Guest, Mike Bray, Alan L. Schmaljohn, Mary Kate Hart *

To determine the ability of antibodies to provide protection from Ebola viruses, monoclonal antibodies (mAbs) to the Ebola glycoprotein were generated and evaluated for efficacy. We identified several protective mAbs directed toward five unique epitopes on Ebola glycoprotein. One of the epitopes is conserved among all Ebola viruses that are known to be pathogenic for humans. Some protective mAbs were also effective therapeutically when administered to mice 2 days after exposure to lethal Ebola virus. The identification of protective mAbs has important implications for developing vaccines and therapies for Ebola virus.

Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702-5011, USA.
*   To whom correspondence should be addressed. E-mail: marykate.hart{at}amedd.army.mil

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