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Science 3 March 2000:
Vol. 287. no. 5458, pp. 1647 - 1651
DOI: 10.1126/science.287.5458.1647
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Reports

Requirement of the Inositol Trisphosphate Receptor for Activation of Store-Operated Ca2+ Channels

Hong-Tao Ma, 1* Randen L. Patterson, 1* Damian B. van Rossum, 1 Lutz Birnbaumer, 2 Katsuhiko Mikoshiba, 3 Donald L. Gill 1dagger

The coupling mechanism between endoplasmic reticulum (ER) calcium ion (Ca2+) stores and plasma membrane (PM) store-operated channels (SOCs) is crucial to Ca2+ signaling but has eluded detection. SOCs may be functionally related to the TRP family of receptor-operated channels. Direct comparison of endogenous SOCs with stably expressed TRP3 channels in human embryonic kidney (HEK293) cells revealed that TRP3 channels differ in being store independent. However, condensed cortical F-actin prevented activation of both SOC and TRP3 channels, which suggests that ER-PM interactions underlie coupling of both channels. A cell-permeant inhibitor of inositol trisphosphate receptor (InsP3R) function, 2-aminoethoxydiphenyl borate, prevented both receptor-induced TRP3 activation and store-induced SOC activation. It is concluded that InsP3Rs mediate both SOC and TRP channel opening and that the InsP3R is essential for maintaining coupling between store emptying and physiological activation of SOCs.

1 Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
2 Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA.
3 Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: dgill{at}umaryland.edu

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Activation of Store-operated Calcium Channels: ASSESSMENT OF THE ROLE OF SNARE-MEDIATED VESICULAR TRANSPORT.
C. C. Scott, W. Furuya, W. S. Trimble, and S. Grinstein (2003)
J. Biol. Chem. 278, 30534-30539
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Regulation of Canonical Transient Receptor Potential (TRPC) Channel Function by Diacylglycerol and Protein Kinase C.
K. Venkatachalam, F. Zheng, and D. L. Gill (2003)
J. Biol. Chem. 278, 29031-29040
   Abstract »    Full Text »    PDF »
Capacitative Cation Entry in Human Myometrial Cells and Augmentation by hTrpC3 Overexpression.
S. G. Shlykov, M. Yang, J. L. Alcorn, and B. M. Sanborn (2003)
Biol Reprod 69, 647-655
   Abstract »    Full Text »    PDF »
TRPC3 Mediates T-cell Receptor-dependent Calcium Entry in Human T-lymphocytes.
S. Philipp, B. Strauss, D. Hirnet, U. Wissenbach, L. Mery, V. Flockerzi, and M. Hoth (2003)
J. Biol. Chem. 278, 26629-26638
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Expression Level of the Canonical Transient Receptor Potential 3 (TRPC3) Channel Determines Its Mechanism of Activation.
G. Vazquez, B. J. Wedel, M. Trebak, G. St. John Bird, and J. W. Putney Jr. (2003)
J. Biol. Chem. 278, 21649-21654
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Transient Receptor Potential Channel Activation Causes a Novel Form of [Ca 2+]i Oscillations and Is Not Involved in Capacitative Ca 2+ Entry in Glial Cells.
M. Grimaldi, M. Maratos, and A. Verma (2003)
J. Neurosci. 23, 4737-4745
   Abstract »    Full Text »    PDF »
2-Aminoethoxydiphenyl Borane Activates a Novel Calcium-Permeable Cation Channel.
F.-J. Braun, O. Aziz, and J. W. Putney Jr. (2003)
Mol. Pharmacol. 63, 1304-1311
   Abstract »    Full Text »    PDF »
The Hepatitis C Virus Core Protein Modulates T Cell Responses by Inducing Spontaneous and Altering T-cell Receptor-triggered Ca2+ Oscillations.
A. Bergqvist, S. Sundstrom, L. Y. Dimberg, E. Gylfe, and M. G. Masucci (2003)
J. Biol. Chem. 278, 18877-18883
   Abstract »    Full Text »    PDF »
The {alpha}-Latrotoxin Mutant LTXN4C Enhances Spontaneous and Evoked Transmitter Release in CA3 Pyramidal Neurons.
M. Capogna, K. E. Volynski, N. J. Emptage, and Y. A. Ushkaryov (2003)
J. Neurosci. 23, 4044-4053
   Abstract »    Full Text »    PDF »
Is Ca2+ Release from Internal Stores Involved in Membrane Excitation in Characean Cells?.
M. Tazawa and M. Kikuyama (2003)
Plant Cell Physiol. 44, 518-526
   Abstract »    Full Text »    PDF »
Inositol 1,4,5-trisphosphate-induced Calcium Release Is Necessary for Generating the Entire Light Response of Limulus Ventral Photoreceptors.
A. Fein (2003)
J. Gen. Physiol. 121, 441-449
   Abstract »    Full Text »    PDF »
Signaling Mechanism for Receptor-activated Canonical Transient Receptor Potential 3 (TRPC3) Channels.
M. Trebak, G. St. J. Bird, R. R. McKay, L. Birnbaumer, and J. W. Putney Jr. (2003)
J. Biol. Chem. 278, 16244-16252
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Connection between Integrins and Cell Activation in Rat Adrenal Glomerulosa Cells: A Role for Arg-Gly-Asp Peptide in the Activation of the p42/p44mapk Pathway and Intracellular Calcium.
S. Campbell, M. Otis, M. Cote, N. Gallo-Payet, and M. D. Payet (2003)
Endocrinology 144, 1486-1495
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Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor.
B. S. Launikonis, M. Barnes, and D. G. Stephenson (2003)
PNAS 100, 2941-2944
   Abstract »    Full Text »    PDF »
PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression.
Y. Yu, M. Sweeney, S. Zhang, O. Platoshyn, J. Landsberg, A. Rothman, and J. X.-J. Yuan (2003)
Am J Physiol Cell Physiol 284, C316-C330
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Regulation of Ca2+ release-activated Ca2+ channels by INAD and Ca2+ influx factor.
Z. Su, D. S. Barker, P. Csutora, T. Chang, R. L. Shoemaker, R. B. Marchase, and J. E. Blalock (2003)
Am J Physiol Cell Physiol 284, C497-C505
   Abstract »    Full Text »    PDF »
Lanthanides Potentiate TRPC5 Currents by an Action at Extracellular Sites Close to the Pore Mouth.
S. Jung, A. Muhle, M. Schaefer, R. Strotmann, G. Schultz, and T. D. Plant (2003)
J. Biol. Chem. 278, 3562-3571
   Abstract »    Full Text »    PDF »


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