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Science 3 March 2000:
Vol. 287. no. 5458, pp. 1606 - 1609
DOI: 10.1126/science.287.5458.1606
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Review

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

Mark Peifer, 1* Paul Polakis 2

The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have provided mechanistic insight into these dual roles. Here we focus on two areas of rapid advance: (i) the machinery that regulates the stability of the key signal transducer, beta -catenin, and (ii) the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.

1 Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA.
2 Genentech, 1 DNA Way, Mail Stop #40, S. San Francisco, CA 94080, USA.
*   To whom correspondence should be addressed. E-mail: peifer{at}unc.edu

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   Abstract »    Full Text »    PDF »
The role of Axin2 in calvarial morphogenesis and craniosynostosis.
H.-M. I. Yu, B. Jerchow, T.-J. Sheu, B. Liu, F. Costantini, J. E. Puzas, W. Birchmeier, and W. Hsu (2005)
Development 132, 1995-2005
   Abstract »    Full Text »    PDF »
Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer.
D. M. Ruden, L. Xiao, M. D. Garfinkel, and X. Lu (2005)
Hum. Mol. Genet. 14, R149-R155
   Abstract »    Full Text »    PDF »
Role for Glycogen Synthase Kinase-3 in NK Cell Cytotoxicity and X-Linked Lymphoproliferative Disease.
A. Aoukaty and R. Tan (2005)
J. Immunol. 174, 4551-4558
   Abstract »    Full Text »    PDF »
RacGap50C Negatively Regulates Wingless Pathway Activity During Drosophila Embryonic Development.
W. M. Jones and A. Bejsovec (2005)
Genetics 169, 2075-2086
   Abstract »    Full Text »    PDF »
Wnt-dependent Regulation of the E-cadherin Repressor Snail.
J. I. Yook, X.-Y. Li, I. Ota, E. R. Fearon, and S. J. Weiss (2005)
J. Biol. Chem. 280, 11740-11748
   Abstract »    Full Text »    PDF »
Frizzled 9 knock-out mice have abnormal B-cell development.
E. A. Ranheim, H. C. K. Kwan, T. Reya, Y.-K. Wang, I. L. Weissman, and U. Francke (2005)
Blood 105, 2487-2494
   Abstract »    Full Text »    PDF »
Systematic Peptide Array-based Delineation of the Differential {beta}-Catenin Interaction with Tcf4, E-Cadherin, and Adenomatous Polyposis Coli.
R. Gail, R. Frank, and A. Wittinghofer (2005)
J. Biol. Chem. 280, 7107-7117
   Abstract »    Full Text »    PDF »
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
J. Liu, A. G. Bang, C. Kintner, A. P. Orth, S. K. Chanda, S. Ding, and P. G. Schultz (2005)
PNAS 102, 1927-1932
   Abstract »    Full Text »    PDF »
Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development.
T. Matsui, A. Raya, Y. Kawakami, C. Callol-Massot, J. Capdevila, C. Rodriguez-Esteban, and J. C. Izpisua Belmonte (2005)
Genes & Dev. 19, 164-175
   Abstract »    Full Text »    PDF »
Interaction and Functional Cooperation between the LIM Protein FHL2, CBP/p300, and {beta}-Catenin.
C. Labalette, C.-A. Renard, C. Neuveut, M.-A. Buendia, and Y. Wei (2004)
Mol. Cell. Biol. 24, 10689-10702
   Abstract »    Full Text »    PDF »
CTNNB1 Mutations and Overexpression of Wnt/{beta}-Catenin Target Genes in WT1-Mutant Wilms' Tumors.
C.-M. Li, C. E. Kim, A. A. Margolin, M. Guo, J. Zhu, J. M. Mason, T. W. Hensle, V. V.V.S. Murty, P. E. Grundy, E. R. Fearon, et al. (2004)
Am. J. Pathol. 165, 1943-1953
   Abstract »    Full Text »    PDF »
Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin.
J. Choi, S. Y. Park, F. Costantini, E.-h. Jho, and C.-K. Joo (2004)
J. Biol. Chem. 279, 49188-49198
   Abstract »    Full Text »    PDF »
Accumulation of Cytoplasmic {beta}-Catenin and Nuclear Glycogen Synthase Kinase 3{beta} in Epstein-Barr Virus-Infected Cells.
D. N. Everly Jr., S. Kusano, and N. Raab-Traub (2004)
J. Virol. 78, 11648-11655
   Abstract »    Full Text »    PDF »
Differential Sensitivity of v-Myb and c-Myb to Wnt-1-induced Protein Degradation.
C. Kanei-Ishii, T. Nomura, J. Tanikawa, E. Ichikawa-Iwata, and S. Ishii (2004)
J. Biol. Chem. 279, 44582-44589
   Abstract »    Full Text »    PDF »
Regulating the Balance between Peroxisome Proliferator-activated Receptor {gamma} and {beta}-Catenin Signaling during Adipogenesis: A GLYCOGEN SYNTHASE KINASE 3{beta} PHOSPHORYLATION-DEFECTIVE MUTANT OF {beta}-CATENIN INHIBITS EXPRESSION OF A SUBSET OF ADIPOGENIC GENES.
J. Liu and S. R. Farmer (2004)
J. Biol. Chem. 279, 45020-45027
   Abstract »    Full Text »    PDF »
Wnt signals across the plasma membrane to activate the {beta}-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.
F. Cong, L. Schweizer, and H. Varmus (2004)
Development 131, 5103-5115
   Abstract »    Full Text »    PDF »
Cellular FLIP Inhibits {beta}-Catenin Ubiquitylation and Enhances Wnt Signaling.
M. Naito, R. Katayama, T. Ishioka, A. Suga, K. Takubo, M. Nanjo, C. Hashimoto, M. Taira, S. Takada, R. Takada, et al. (2004)
Mol. Cell. Biol. 24, 8418-8427
   Abstract »    Full Text »    PDF »
Wnt/{beta}-Catenin and Estrogen Signaling Converge in Vivo.
A. P. Kouzmenko, K.-i. Takeyama, S. Ito, T. Furutani, S. Sawatsubashi, A. Maki, E. Suzuki, Y. Kawasaki, T. Akiyama, T. Tabata, et al. (2004)
J. Biol. Chem. 279, 40255-40258
   Abstract »    Full Text »    PDF »


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