Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 February 2000:
Vol. 287. no. 5457, pp. 1431 - 1433
DOI: 10.1126/science.287.5457.1431

Review

Stem Cells in Epithelial Tissues

J. M. W. Slack

Most, if not all, epithelial tissues contain stem cells. They are responsible for normal tissue renewal or for regeneration following damage. Our present knowledge of their properties is limited and is mainly derived from studies of cell kinetics and from clonal analysis.

Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK. E-mail: j.m.w.slack{at}bath.ac.uk


Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Local Delivery of Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cells Using Bioscaffold for Modality of Unhealing Bone Fracture.
Y. Mifune, T. Matsumoto, A. Kawamoto, R. Kuroda, T. Shoji, H. Iwasaki, S.-M. Kwon, M. Miwa, M. Kurosaka, and T. Asahara (2008)
Stem Cells 26, 1395-1405
   Abstract »    Full Text »    PDF »
Label-retaining cells of the bladder: candidate urothelial stem cells.
E. A. Kurzrock, D. K. Lieu, L. A. deGraffenried, C. W. Chan, and R. R. Isseroff (2008)
Am J Physiol Renal Physiol 294, F1415-F1421
   Abstract »    Full Text »    PDF »
Label-retaining Cells in the Rat Submandibular Gland.
M. Kimoto, Y. Yura, M. Kishino, S. Toyosawa, and Y. Ogawa (2008)
J. Histochem. Cytochem. 56, 15-24
   Abstract »    Full Text »    PDF »
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.
D. H. D. Gray, N. Seach, T. Ueno, M. K. Milton, A. Liston, A. M. Lew, C. C. Goodnow, and R. L. Boyd (2006)
Blood 108, 3777-3785
   Abstract »    Full Text »    PDF »
Therapeutic Potential of Vasculogenesis and Osteogenesis Promoted by Peripheral Blood CD34-Positive Cells for Functional Bone Healing.
T. Matsumoto, A. Kawamoto, R. Kuroda, M. Ishikawa, Y. Mifune, H. Iwasaki, M. Miwa, M. Horii, S. Hayashi, A. Oyamada, et al. (2006)
Am. J. Pathol. 169, 1440-1457
   Abstract »    Full Text »    PDF »
Mesenchymal stem cells reside in virtually all post-natal organs and tissues.
L. d. S. Meirelles, P. C. Chagastelles, and N. B. Nardi (2006)
J. Cell Sci. 119, 2204-2213
   Abstract »    Full Text »    PDF »
Formation of Pancreatic Duct Epithelium from Bone Marrow During Neonatal Development.
X. Wang, S. Ge, I. Gonzalez, G. McNamara, C. B. Rountree, K. K. Xi, G. Huang, A. Bhushan, and G. M. Crooks (2006)
Stem Cells 24, 307-314
   Abstract »    Full Text »    PDF »
Increased Circulating Endothelial Progenitor Cells Are Associated with Survival in Acute Lung Injury.
E. L. Burnham, W. R. Taylor, A. A. Quyyumi, M. Rojas, K. L. Brigham, and M. Moss (2005)
Am. J. Respir. Crit. Care Med. 172, 854-860
   Abstract »    Full Text »    PDF »
Breast Cancer Resistance Protein-Mediated Efflux of Androgen in Putative Benign and Malignant Prostate Stem Cells.
W. J. Huss, D. R. Gray, N. M. Greenberg, J. L. Mohler, and G. J. Smith (2005)
Cancer Res. 65, 6640-6650
   Abstract »    Full Text »    PDF »
Aquaporin-3 Expression in Human Fetal Airway Epithelial Progenitor Cells.
A. Avril-Delplanque, I. Casal, N. Castillon, J. Hinnrasky, E. Puchelle, and B. Peault (2005)
Stem Cells 23, 992-1001
   Abstract »    Full Text »    PDF »
Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin.
C. Roh, Q. Tao, and S. Lyle (2004)
Physiol Genomics 19, 207-217
   Abstract »    Full Text »    PDF »
Clonogenicity of Human Endometrial Epithelial and Stromal Cells.
R. W.S. Chan, K. E. Schwab, and C. E. Gargett (2004)
Biol Reprod 70, 1738-1750
   Abstract »    Full Text »    PDF »
Intestinal villous M cells: An antigen entry site in the mucosal epithelium.
M. H. Jang, M.-N. Kweon, K. Iwatani, M. Yamamoto, K. Terahara, C. Sasakawa, T. Suzuki, T. Nochi, Y. Yokota, P. D. Rennert, et al. (2004)
PNAS 101, 6110-6115
   Abstract »    Full Text »    PDF »
A subset of mouse tracheal epithelial basal cells generates large colonies in vitro.
K. G. Schoch, A. Lori, K. A. Burns, T. Eldred, J. C. Olsen, and S. H. Randell (2004)
Am J Physiol Lung Cell Mol Physiol 286, L631-L642
   Abstract »    Full Text »    PDF »
High Incidence of Thymic Epithelial Tumors in E2F2 Transgenic Mice.
B. Scheijen, M. Bronk, T. van der Meer, D. De Jong, and R. Bernards (2004)
J. Biol. Chem. 279, 10476-10483
   Abstract »    Full Text »    PDF »
Human Pancreatic Islet-Derived Progenitor Cell Engraftment in Immunocompetent Mice.
E. J. Abraham, S. Kodama, J. C. Lin, M. Ubeda, D. L. Faustman, and J. F. Habener (2004)
Am. J. Pathol. 164, 817-830
   Abstract »    Full Text »    PDF »
Measuring stem cell frequency in epidermis: A quantitative in vivo functional assay for long-term repopulating cells.
T. E. Schneider, C. Barland, A. M. Alex, M. L. Mancianti, Y. Lu, J. E. Cleaver, H. J. Lawrence, and R. Ghadially (2003)
PNAS 100, 11412-11417
   Abstract »    Full Text »    PDF »
Adult Stem Cells for Tissue Repair -- A New Therapeutic Concept?.
M. Korbling and Z. Estrov (2003)
N. Engl. J. Med. 349, 570-582
   Full Text »    PDF »
EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties.
M.-A. Deugnier, M. M. Faraldo, B. Janji, P. Rousselle, J. P. Thiery, and M. A. Glukhova (2002)
J. Cell Biol. 159, 453-463
   Abstract »    Full Text »    PDF »
Terminal Bronchioles Harbor a Unique Airway Stem Cell Population That Localizes to the Bronchoalveolar Duct Junction.
A. Giangreco, S. D. Reynolds, and B. R. Stripp (2002)
Am. J. Pathol. 161, 173-182
   Abstract »    Full Text »    PDF »
Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis.
A. Tsujimura, Y. Koikawa, S. Salm, T. Takao, S. Coetzee, D. Moscatelli, E. Shapiro, H. Lepor, T.-T. Sun, and E. L. Wilson (2002)
J. Cell Biol. 157, 1257-1265
   Abstract »    Full Text »    PDF »
Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants.
R C Fitzgerald, B A Onwuegbusi, M Bajaj-Elliott, I T Saeed, W R Burnham, and M J G Farthing (2002)
Gut 50, 451-459
   Abstract »    Full Text »    PDF »
Cell Density and N-Cadherin Interactions Regulate Cell Proliferation in the Sensory Epithelia of the Inner Ear.
M. E. Warchol (2002)
J. Neurosci. 22, 2607-2616
   Abstract »    Full Text »    PDF »
Polyploidy associated with oxidative injury attenuates proliferative potential of cells.
G. R. Gorla, H. Malhi, and S. Gupta (2002)
J. Cell Sci. 114, 2943-2951
   Abstract »    Full Text »    PDF »
A Bioartificial Liver--State of the Art.
A. J. Strain and J. M. Neuberger (2002)
Science 295, 1005-1009
   Abstract »    Full Text »    PDF »
Biology of Oral Mucosa and Esophagus.
C. A. Squier and M. J. Kremer (2001)
J Natl Cancer Inst Monographs 2001, 7-15
   Abstract »    Full Text »    PDF »
Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation.
J. L. Burns and A. B. Hassan (2001)
Development 128, 3819-3830
   Abstract »    Full Text »    PDF »
Bile reflux gastritis and Barrett's oesophagus: further evidence of a role for duodenogastro-oesophageal reflux?.
M F Dixon, P M Neville, N P Mapstone, P Moayyedi, and A T R Axon (2001)
Gut 49, 359-363
   Abstract »    Full Text »    PDF »
Prospects for intervention in gastric carcinogenesis: reversibility of gastric atrophy and intestinal metaplasia.
M F DIXON (2001)
Gut 49, 2-4
   Full Text »    PDF »
Evidence for Stem-Cell Niches in the Tracheal Epithelium.
D. W. Borthwick, M. Shahbazian, Q. Todd Krantz, J. R. Dorin, and S. H. Randell (2001)
Am. J. Respir. Cell Mol. Biol. 24, 662-670
   Abstract »    Full Text »    PDF »
Clara Cell Secretory Protein-Expressing Cells of the Airway Neuroepithelial Body Microenvironment Include a Label-Retaining Subset and Are Critical for Epithelial Renewal after Progenitor Cell Depletion.
K. U. Hong, S. D. Reynolds, A. Giangreco, C. M. Hurley, and B. R. Stripp (2001)
Am. J. Respir. Cell Mol. Biol. 24, 671-681
   Abstract »    Full Text »    PDF »
Mesenchymal Stem Cells.
J. J. Minguell, A. Erices, and P. Conget (2001)
Experimental Biology and Medicine 226, 507-520
   Abstract »    Full Text »    PDF »
Adult-Derived Stem Cells from the Liver Become Myocytes in the Heart in Vivo.
N. N. Malouf, W. B. Coleman, J. W. Grisham, R. A. Lininger, V. J. Madden, M. Sproul, and P. A. W. Anderson (2001)
Am. J. Pathol. 158, 1929-1935
   Abstract »    Full Text »    PDF »
Cell Senescence and Its Implications for Nephrology.
A. MELK and P. F. HALLORAN (2001)
J. Am. Soc. Nephrol. 12, 385-393
   Full Text »
Identification and isolation of human prostate epithelial stem cells based on {alpha}2{beta}1-integrin expression.
A. T. Collins, F. K. Habib, N. J. Maitland, and D. E. Neal (2001)
J. Cell Sci. 114, 3865-3872
   Abstract »    Full Text »    PDF »
Bioengineered Corneas -- The Promise and the Challenge.
I. R. Schwab and R. R. Isseroff (2000)
N. Engl. J. Med. 343, 136-138
   Full Text »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)