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Science 18 February 2000:
Vol. 287. no. 5456, pp. 1276 - 1279
DOI: 10.1126/science.287.5456.1276
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Reports

Mitochondrial FtsZ in a Chromophyte Alga

Peter L. Beech, 13* Thao Nheu, 3dagger Thomas Schultz, 3ddagger Shane Herbert, 1 Trevor Lithgow, 4 Paul R. Gilson, 23 Geoffrey I. McFadden 23

A homolog of the bacterial cell division gene ftsZ was isolated from the alga Mallomonas splendens. The nuclear-encoded protein (MsFtsZ-mt) was closely related to FtsZs of the alpha -proteobacteria, possessed a mitochondrial targeting signal, and localized in a pattern consistent with a role in mitochondrial division. Although FtsZs are known to act in the division of chloroplasts, MsFtsZ-mt appears to be a mitochondrial FtsZ and may represent a mitochondrial division protein.

1 Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, 221 Burwood Highway, Melbourne, 3125, Australia.
2 Plant Cell Biology Research Centre,
3 School of Botany,
4 Department of Biochemistry and Molecular Biology, University of Melbourne, 3010, Australia.
*   To whom correspondence should be addressed. E-mail: plbeech{at}deakin.edu.au

dagger    Present address: Ludwig Institute for Cancer Research, Royal Melbourne Hospital, 3050, Australia.

ddagger    Present address: The Scripps Research Institute, 11055 North Torrey Pines Road, La Jolla, CA 92037, USA.

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