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Science 21 January 2000:
Vol. 287. no. 5452, pp. 491 - 495
DOI: 10.1126/science.287.5452.491
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Reports

Role of the Enteric Nervous System in the Fluid and Electrolyte Secretion of Rotavirus Diarrhea

Ove Lundgren, 1* Attila Timar Peregrin, 1 Kjell Persson, 1 Shirin Kordasti, 1 Ingrid Uhnoo, 2 Lennart Svensson 3

The mechanism underlying the intestinal fluid loss in rotavirus diarrhea, which often afflicts children in developing countries, is not known. One hypothesis is that the rotavirus evokes intestinal fluid and electrolyte secretion by activation of the nervous system in the intestinal wall, the enteric nervous system (ENS). Four different drugs that inhibit ENS functions were used to obtain experimental evidence for this hypothesis in mice in vitro and in vivo. The involvement of the ENS in rotavirus diarrhea indicates potential sites of action for drugs in the treatment of the disease.

1 Department of Physiology, Göteborg University, Box 432, S-405 30 Göteborg, Sweden.
2 Section of Infectious Diseases, Department of Medical Sciences, University Hospital, S-751 85 Uppsala, Sweden.
3 Department of Virology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden.
*   To whom correspondence should be addressed. E-mail: ove.lundgren{at}fysiologi.gu.se

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