Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 January 2000:
Vol. 287. no. 5451, pp. 324 - 327
DOI: 10.1126/science.287.5451.324
Prev | Table of Contents

Reports

Regulation of JNK by Src During Drosophila Development

Minoru Tateno, Yasuyoshi Nishida, Takashi Adachi-Yamada *

In Drosophila, the Jun amino-terminal kinase (JNK) homolog Basket (Bsk) is required for epidermal closure. Mutants for Src42A, a Drosophila c-src protooncogene homolog, are described. Src42A functions in epidermal closure during both embryogenesis and metamorphosis. The severity of the epidermal closure defect in the Src42A mutant depended on the amount of Bsk activity, and the amount of Bsk activity depended on the amount of Src42A. Thus, activation of the Bsk pathway is required downstream of Src42A in epidermal closure. This work confirms mammalian studies that demonstrated a physiological link between Src and JNK.

Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
*   To whom correspondence should be addressed. E-mail: adachi{at}bio.nagoya-u.ac.jp

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
M. Shindo, H. Wada, M. Kaido, M. Tateno, T. Aigaki, L. Tsuda, and S. Hayashi (2008)
Development 135, 1355-1364
   Abstract »    Full Text »    PDF »
Transcription factor NF-Y is involved in regulation of the JNK pathway during Drosophila thorax development..
Y. Yoshioka, O. Suyari, and M. Yamaguchi (2008)
Genes Cells 13, 117-130
   Abstract »    Full Text »    PDF »
Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster.
J. Chen, X. Shi, R. Padmanabhan, Q. Wang, Z. Wu, S. C. Stevenson, M. Hild, D. Garza, and H. Li (2008)
Genome Res. 18, 123-136
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Receptor-1 Can Function through a G{alpha}q/11-beta-Arrestin-1 Signaling Complex.
Y. Kawamata, T. Imamura, J. L. Babendure, J.-C. Lu, T. Yoshizaki, and J. M. Olefsky (2007)
J. Biol. Chem. 282, 28549-28556
   Abstract »    Full Text »    PDF »
Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration.
K. E. Harris and S. K. Beckendorf (2007)
Development 134, 2017-2025
   Abstract »    Full Text »    PDF »
The Nonmuscle Myosin Phosphatase PP1{beta} (flapwing) Negatively Regulates Jun N-Terminal Kinase in Wing Imaginal Discs of Drosophila.
J. Kirchner, S. Gross, D. Bennett, and L. Alphey (2007)
Genetics 175, 1741-1749
   Abstract »    Full Text »    PDF »
The Fes/Fer non-receptor tyrosine kinase cooperates with Src42A to regulate dorsal closure in Drosophila.
M. J. Murray, C. M. Davidson, N. M. Hayward, and A. H. Brand (2006)
Development 133, 3063-3073
   Abstract »    Full Text »    PDF »
Drosophila Dok is required for embryonic dorsal closure.
R. Biswas, D. Stein, and E. R. Stanley (2006)
Development 133, 217-227
   Abstract »    Full Text »    PDF »
Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis.
D. G. McEwen and M. Peifer (2005)
Development 132, 3935-3946
   Abstract »    Full Text »    PDF »
Coagulation Cascade Activation Causes CC Chemokine Receptor-2 Gene Expression and Mononuclear Cell Activation in Hemodialysis Patients.
G. Pertosa, S. Simone, M. Soccio, D. Marrone, L. Gesualdo, F. P. Schena, and G. Grandaliano (2005)
J. Am. Soc. Nephrol. 16, 2477-2486
   Abstract »    Full Text »    PDF »
Tec29 controls actin remodeling and endoreplication during invagination of the Drosophila embryonic salivary glands.
V. Chandrasekaran and S. K. Beckendorf (2005)
Development 132, 3515-3524
   Abstract »    Full Text »    PDF »
Tobacco Smoke Control of Mucin Production in Lung Cells Requires Oxygen Radicals AP-1 and JNK.
E. Gensch, M. Gallup, A. Sucher, D. Li, A. Gebremichael, H. Lemjabbar, A. Mengistab, V. Dasari, J. Hotchkiss, J. Harkema, et al. (2004)
J. Biol. Chem. 279, 39085-39093
   Abstract »    Full Text »    PDF »
Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways.
R. D. Read, E. A. Bach, and R. L. Cagan (2004)
Mol. Cell. Biol. 24, 6676-6689
   Abstract »    Full Text »    PDF »
src64 and tec29 are required for microfilament contraction during Drosophila cellularization.
J. H. Thomas and E. Wieschaus (2004)
Development 131, 863-871
   Abstract »    Full Text »    PDF »
bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis.
D. H. Tran and C. A. Berg (2003)
Development 130, 6273-6282
   Abstract »    Full Text »    PDF »
Inhibition of Tumor Necrosis Factor-{alpha}-Induced SHP-2 Phosphatase Activity by Shear Stress: A Mechanism to Reduce Endothelial Inflammation.
N. Lerner-Marmarosh, M. Yoshizumi, W. Che, J. Surapisitchat, H. Kawakatsu, M. Akaike, B. Ding, Q. Huang, C. Yan, B. C. Berk, et al. (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 1775-1781
   Abstract »    Full Text »    PDF »
Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation.
R. J. Kelso, A. M. Hudson, and L. Cooley (2002)
J. Cell Biol. 156, 703-713
   Abstract »    Full Text »    PDF »
Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice.
T. S. Stappenbeck and J. I. Gordon (2001)
Development 128, 2603-2614
   Abstract »    Full Text »    PDF »
Ras-Dependent Regulation of c-Jun Phosphorylation Is Mediated by the Ral Guanine Nucleotide Exchange Factor-Ral Pathway.
N. D. de Ruiter, R. M. F. Wolthuis, H. van Dam, B. M. T. Burgering, and J. L. Bos (2000)
Mol. Cell. Biol. 20, 8480-8488
   Abstract »    Full Text »
Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS.
M. A. Lomaga, J. T. Henderson, A. J. Elia, J. Robertson, R. S. Noyce, W.-C. Yeh, and T. W. Mak (2000)
J. Neurosci. 20, 7384-7393
   Abstract »    Full Text »    PDF »
Src and Cas Mediate JNK Activation but Not ERK1/2 and p38 Kinases by Reactive Oxygen Species.
M. Yoshizumi, J.-i. Abe, J. Haendeler, Q. Huang, and B. C. Berk (2000)
J. Biol. Chem. 275, 11706-11712
   Abstract »    Full Text »    PDF »
The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure.
R. Fernandez, F. Takahashi, Z. Liu, R. Steward, D. Stein, and E. R. Stanley (2000)
Genes & Dev. 14, 604-614
   Abstract »    Full Text »
The Rac GTPase-activating Protein RotundRacGAP Interferes with Drac1 and Dcdc42 Signalling in Drosophila melanogaster.
K. Raymond, E. Bergeret, M.-C. Dagher, R. Breton, R. Griffin-Shea, and M.-O. Fauvarque (2001)
J. Biol. Chem. 276, 35909-35916
   Abstract »    Full Text »    PDF »
Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation.
R. J. Kelso, A. M. Hudson, and L. Cooley (2002)
J. Cell Biol. 156, 703-713
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)