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Science 14 January 2000:
Vol. 287. no. 5451, pp. 321 - 324
DOI: 10.1126/science.287.5451.321
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Reports

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

Kenji Miyado, 1* Gen Yamada, 23* Shuichi Yamada, 4* Hidetoshi Hasuwa, 1 Yasuhiro Nakamura, 5 Fuminori Ryu, 1 Kentaro Suzuki, 2 Kenichiro Kosai, 2 Kimiko Inoue, 6 Atsuo Ogura, 6 Masaru Okabe, 7 Eisuke Mekada 12dagger

CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9-/- mice were born healthy and grew normally. However, the litter size from CD9-/- females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion.

1 Institute of Life Science, Kurume University, Kurume, Fukuoka 839-0861, Japan.
2 Research Center for Innovative Cancer Therapy, Kurume University, Fukuoka 830-0011, Japan.
3 Center of Animal Resources and Development, Kumamoto University, Kumamoto 860-0811, Japan.
4 Program for Promotion of Basic Research Activities for Innovative Biosciences, Tokyo 105-0001, Japan.
5 St. Mary's Hospital, Kurume, Fukuoka 830-0047, Japan.
6 National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.
7 Genome Information Research Center, Osaka University, Suita, Osaka 565-0861, Japan.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: emekada{at}lsi.kurume-u.ac.jp

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