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Science 14 January 2000:
Vol. 287. no. 5451, pp. 319 - 321
DOI: 10.1126/science.287.5451.319
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Reports

Severely Reduced Female Fertility in CD9-Deficient Mice

François Le Naour, Eric Rubinstein, Claude Jasmin, Michel Prenant, Claude Boucheix *

CD9 is a widely expressed cell surface molecule that belongs to the tetraspanin superfamily of proteins. The tetraspanins CD9, KAI-1/CD82, and CD63 are involved in metastasis suppression, an effect that may be related to their association with beta 1 integrins. Knockout mice lacking CD9 were created to evaluate the physiological importance of CD9. CD9-/- females displayed a severe reduction of fertility. Oocytes were ovulated but were not successfully fertilized because sperm did not fuse with the oocytes from CD9-/- females. Thus, CD9 appears to be essential for sperm-egg fusion, a process involving the CD9-associated integrin alpha 6beta 1.

Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 268, Hôpital Paul-Brousse, 94800 Villejuif, France.
*   To whom correspondence should be addressed. E-mail: boucheix{at}infobiogen.fr

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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