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Science 14 January 2000:
Vol. 287. no. 5451, pp. 314 - 316
DOI: 10.1126/science.287.5451.314
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Reports

A Population of Murine gamma &dgr; T Cells That Recognize an Inducible MHC Class Ib Molecule

Michael P. Crowley, 1* Aude M. Fahrer, 2dagger Nicole Baumgarth, 3 Johannes Hampl, 2ddagger Ines Gutgemann, 2§ Luc Teyton, 4 Yueh-hsiu Chien 12parallel

Although gamma delta T cells are implicated in regulating immune responses, gamma delta T cell-ligand pairs that could mediate such regulatory functions have not been identified. Here, the expression of the major histocompatibility complex (MHC) class Ib T22 and the closely related T10 molecules is shown to be activation-induced, and they confer specificity to about 0.4% of the gamma delta T cells in normal mice. Thus, the increased expression of T22 and/or T10 might trigger immunoregulatory gamma delta T cells during immune responses. Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for gamma delta T cell activation.

1 Program in Immunology,
2 Department of Microbiology and Immunology, and
3 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
4 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
*   Present address: Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27705, USA.

dagger    Present address: Division of Immunology and Cell Biology, John Curtin School of Medical Research, Canberra, ACT, Australia.

ddagger    Present address: Stanford Research Institute, Menlo Park, CA 94025, USA.

§   Present address: Department of Pathology, University of California San Francisco School of Medicine, San Francisco, CA 94143, USA.

parallel    To whom correspondence should be addressed. E-mail: chien{at}leland.stanford.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)