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Science 14 January 2000:
Vol. 287. no. 5451, pp. 248 - 251
DOI: 10.1126/science.287.5451.248
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Review

Memory--a Century of Consolidation

James L. McGaugh

The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.

The author is at the Center for the Neurobiology of Learning and Memory and the Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA. E-mail: jlmcgaug{at}uci.edu

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