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Science 7 January 2000:
Vol. 287. no. 5450, pp. 134 - 137
DOI: 10.1126/science.287.5450.134
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Reports

Tbx5 and the Retinotectum Projection

Kazuko Koshiba-Takeuchi, 1* Jun K. Takeuchi, 1* Ken Matsumoto, 1 Tsuyoshi Momose, 1 Kenichiro Uno, 1 Veit Hoepker, 2 Keiko Ogura, 1 Naoki Takahashi, 1 Harukazu Nakamura, 3 Kunio Yasuda, 1 Toshihiko Ogura 1dagger

Dorsal and ventral aspects of the eye are distinct from the early stages of development. The developing eye cup grows dorsally, and the choroidal fissure is formed on its ventral side. Retinal axons from the dorsal and ventral retina project to the ventral and dorsal tectum, respectively. Misexpression of the Tbx5 gene induced dorsalization of the ventral side of the eye and altered projections of retinal ganglion cell axons. Thus, Tbx5 is involved in eye morphogenesis and is a topographic determinant of the visual projections between retina and tectum.

1 Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, Japan 630-0101.
2 Department of Biology, 0357, University of California, San Diego, La Jolla, CA 92093-0357, USA.
3 Department of Molecular Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, 4-1, Seiryo, Aoba, Sendai, Miyagi, Japan 980-77.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: ogura{at}bs.aist-nara.ac.jp

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