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Science 24 December 1999:
Vol. 286. no. 5449, pp. 2468 - 2474
DOI: 10.1126/science.286.5449.2468
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Research Articles

Genetic Definition and Sequence Analysis of Arabidopsis Centromeres

Gregory P. Copenhaver, 1 Kathryn Nickel, 1 Takashi Kuromori, 1 Maria-Ines Benito, 2 Samir Kaul, 2 Xiaoying Lin, 2 Michael Bevan, 3 George Murphy, 3 Barbara Harris, 4 Laurence D. Parnell, 5 W. Richard McCombie, 5 Robert A. Martienssen, 5 Marco Marra, 6 Daphne Preuss 1*

High-precision genetic mapping was used to define the regions that contain centromere functions on each natural chromosome in Arabidopsis thaliana. These regions exhibited dramatic recombinational repression and contained complex DNA surrounding large arrays of 180-base pair repeats. Unexpectedly, the DNA within the centromeres was not merely structural but also encoded several expressed genes. The regions flanking the centromeres were densely populated by repetitive elements yet experienced normal levels of recombination. The genetically defined centromeres were well conserved among Arabidopsis ecotypes but displayed limited sequence homology between different chromosomes, excluding repetitive DNA. This investigation provides a platform for dissecting the role of individual sequences in centromeres in higher eukaryotes.

1 University of Chicago, Department of Molecular Genetics and Cell Biology, 1103 East 57 Street, Chicago, IL 60637, USA.
2 The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
3 John Innes Centre, Colney Lane, Norwich NR4 7UJ, UK.
4 The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
5 Cold Spring Harbor Laboratories, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
6 Washington University Genome Sequencing Center, 4444 Forest Park Boulevard, St. Louis, MO 63108, USA.
*   To whom correspondence should be addressed. E-mail: dpreuss{at}midway.uchicago.edu

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