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Science 10 December 1999:
Vol. 286. no. 5447, pp. 2156 - 2159
DOI: 10.1126/science.286.5447.2156
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Reports

Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies

Adrian F. Ochsenbein, 1* Thomas Fehr, 1 Claudia Lutz, 2 Mark Suter, 3 Frank Brombacher, 4 Hans Hengartner, 1 Rolf M. Zinkernagel 1

Natural antibodies are often dismissed from immunological analysis as "background," but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary lymphoid organs.

1 Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.
2 Max Planck Institute for Immunobiology, Freiburg, Germany.
3 M. Suter, Institute for Virology, University of Zurich, Switzerland.
4 F. Brombacher, Department of Immunology, Groote Schuur Hospital, University of Cape Town, 7925 Cape Town, South Africa.
*   To whom correspondence should be addressed.

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J. Immunol. 168, 4257-4261
   Abstract »    Full Text »    PDF »
Expression of ABO or related antigenic carbohydrates on viral envelopes leads to neutralization in the presence of serum containing specific natural antibodies and complement.
A. F. Preece, K. M. Strahan, J. Devitt, F.-i. Yamamoto, and K. Gustafsson (2002)
Blood 99, 2477-2482
   Abstract »    Full Text »    PDF »
B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen.
H. Wardemann, T. Boehm, N. Dear, and R. Carsetti (2002)
J. Exp. Med. 195, 771-780
   Abstract »    Full Text »    PDF »
IL-4 and T Cells Are Required for the Generation of IgG1 Isotype Antibodies Against Cardiolipin.
K. Fischer, H. Collins, M. Taniguchi, S. H. E. Kaufmann, and U. E. Schaible (2002)
J. Immunol. 168, 2689-2694
   Abstract »    Full Text »    PDF »
Role of an Intact Splenic Microarchitecture in Early Lymphocytic Choriomeningitis Virus Production.
S. Muller, L. Hunziker, S. Enzler, M. Buhler-Jungo, J. P. Di Santo, R. M. Zinkernagel, and C. Mueller (2002)
J. Virol. 76, 2375-2383
   Abstract »    Full Text »    PDF »
Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant.
K. Balabanian, A. Foussat, L. Bouchet-Delbos, J. Couderc, R. Krzysiek, A. Amara, F. Baleux, A. Portier, P. Galanaud, and D. Emilie (2002)
Blood 99, 427-436
   Abstract »    Full Text »    PDF »
Natural Antibody Affects Survival of the Spirochete Borrelia burgdorferi within Feeding Ticks.
A. A. Belperron and L. K. Bockenstedt (2001)
Infect. Immun. 69, 6456-6462
   Abstract »    Full Text »    PDF »


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