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Science 10 December 1999:
Vol. 286. no. 5447, pp. 2156 - 2159
DOI: 10.1126/science.286.5447.2156
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Reports

Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies

Adrian F. Ochsenbein, 1* Thomas Fehr, 1 Claudia Lutz, 2 Mark Suter, 3 Frank Brombacher, 4 Hans Hengartner, 1 Rolf M. Zinkernagel 1

Natural antibodies are often dismissed from immunological analysis as "background," but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary lymphoid organs.

1 Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.
2 Max Planck Institute for Immunobiology, Freiburg, Germany.
3 M. Suter, Institute for Virology, University of Zurich, Switzerland.
4 F. Brombacher, Department of Immunology, Groote Schuur Hospital, University of Cape Town, 7925 Cape Town, South Africa.
*   To whom correspondence should be addressed.

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Marginal Zone Macrophages and Immune Responses Against Viruses.
S. Oehen, B. Odermatt, U. Karrer, H. Hengartner, R. Zinkernagel, and C. Lopez-Macias (2002)
J. Immunol. 169, 1453-1458
   Abstract »    Full Text »    PDF »
Natural recognition repertoire and the evolutionary emergence of the combinatorial immune system.
J. J. MARCHALONIS, S. KAVERI, S. LACROIX-DESMAZES, and M. D. KAZATCHKINE (2002)
FASEB J 16, 842-848
   Abstract »    Full Text »    PDF »
Comparative study of different enzyme immunoassays for measurement of IgM and IgA rheumatoid factors.
S Bas, T V Perneger, E Kunzle, and T L Vischer (2002)
Ann Rheum Dis 61, 505-510
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B Cells Control the Migration of a Subset of Dendritic Cells into B Cell Follicles Via CXC Chemokine Ligand 13 in a Lymphotoxin-Dependent Fashion.
P. Yu, Y. Wang, R. K. Chin, L. Martinez-Pomares, S. Gordon, M. H. Kosco-Vibois, J. Cyster, and Y.-X. Fu (2002)
J. Immunol. 168, 5117-5123
   Abstract »    Full Text »    PDF »
Specificity mapping of human anti-T cell receptor monoclonal natural antibodies: defining the properties of epitope recognition promiscuity.
I. F. ROBEY, A. B. EDMUNDSON, S. F. SCHLUTER, D. E. YOCUM, and J. J. MARCHALONIS (2002)
FASEB J 16, 642-652
   Abstract »    Full Text »    PDF »
Two B-1 or Not To Be One.
T. L. Rothstein (2002)
J. Immunol. 168, 4257-4261
   Abstract »    Full Text »    PDF »


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