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Science 3 December 1999:
Vol. 286. no. 5446, pp. 1965 - 1968
DOI: 10.1126/science.286.5446.1965
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Reports

Organogenic Role of B Lymphocytes in Mucosal Immunity

Tatyana V. Golovkina, 1 Mark Shlomchik, 23 Lynn Hannum, 2 Alexander Chervonsky 1*

Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.

1 Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
2 Section of Immunobiology,
3 Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
*   To whom correspondence should be addressed. E-mail: avc{at}aretha.jax.org

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Science. ISSN 0036-8075 (print), 1095-9203 (online)