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Science 3 December 1999:
Vol. 286. no. 5446, pp. 1921 - 1925
DOI: 10.1126/science.286.5446.1921
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Research Articles

Predicting the Evolution of Human Influenza A

Robin M. Bush, 1* Catherine A. Bender, 2 Kanta Subbarao, 2 Nancy J. Cox, 2 Walter M. Fitch 1

Eighteen codons in the HA1 domain of the hemagglutinin genes of human influenza A subtype H3 appear to be under positive selection to change the amino acid they encode. Retrospective tests show that viral lineages undergoing the greatest number of mutations in the positively selected codons were the progenitors of future H3 lineages in 9 of 11 recent influenza seasons. Codons under positive selection were associated with antibody combining site A or B or the sialic acid receptor binding site. However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift.

1 Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.
2 Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
*   To whom correspondence should be addressed. E-mail: rmbush{at}uci.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)